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Fig. 1 | Biomarker Research

Fig. 1

From: Circulating cell-free DNA (cfDNA) in patients with medullary thyroid carcinoma is characterized by specific fragmentation and methylation changes with diagnostic value

Fig. 1

Evaluation of cfDNA fragmentation. (A) SFF was calculated as the proportion of short fragments as detailed in supplementary methods in MTC patients and healthy donors (controls, HD) plasma samples. Unpaired t-test * p < 0.05 (B) ROC curve of SFF in a cohort of 8 MTC and 6 healthy donors subjects (Area under the curve AUC = 0.8750; p-value = 0.0201). Black line = sensitivity, red line = identity. (C) SFF in MTC patient before (T0) and three months after the surgical resection (T1). (D) SFF in post-surgery 11 MTC patients and 15 healthy donors (HD) plasma samples. SD (Structural disease); BD (Biochemical disease); DF (Disease Free) compared to HD (Healthy Honors; mean value in black line) SFF.

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Biomarker Research

ISSN: 2050-7771

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