The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance

Sicking, Mark; Falke, Isabel; Löblein, Maria T.; Eich, Hans Th.; Götte, Martin; Greve, Burkhard; Troschel, Fabian M.

doi:10.1186/s40364-023-00516-2

Biomarker Research

Table 1 Summary of the effects mediated by MSI-1 or MSI-2 in the different female cancer entities

From: The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance

Tumor entity	Characteristics	Musashi-1	Musashi-2
Breast cancer	Expression	Overexpressed in cancer [61]	Overexpressed in cancer [60] except for TNBC [17]
	Cancer stem cell	CSC marker [50]	CSC marker [73]
	Proliferation	Induces proliferation [66]	Induces or blocks proliferation, unclear [17, 66]
	Therapy	Marker of radioresistance [68]	Marker of radioresistance at least in combination with MSI-1 [30]
	Prognosis	Negative prognostic marker [57]	Positive prognostic marker [75] No significance once analyzed separately for estrogen receptor positive and negative tumors
	Future perspective	In vivo studies needed	Clarification regarding role as oncogene or tumor suppressor necessary
Ovarian cancer	Expression	Overexpression in cancer [83]	Overexpression in cancer [84]
	Cancer stem cell	CSC marker [31]	CSC marker [31]
	Proliferation	Anti-proliferative in one of two cell lines [31]	Anti-proliferative in one of two cell lines [31]
	Therapy	Marker of radio- and chemoresistance [82]	Marker of radio- and chemoresistance [84]
	Prognosis	Negative prognostic marker [83]	N.a.
	Future perspective	In vivo studies needed	In vivo studies needed, prognostic relevance unclear
Endometrial cancer	Expression	Overexpressed in cancer [89, 90]	N.a.
	Cancer stem cell	CSC marker [92]	N.a.
	Proliferation	Induces proliferation [92]	N.a.
	Therapy	Marker of radioresistance [92]	N.a.
	Prognosis	Negative prognostic marker [13]	N.a.
	Future perspectives	Translational assessment necessary	No prior investigation
Cervical cancer	Expression	Overexpressed in cancer [96, 97]	Overexpressed and associated with lymph node metastasis [79]
	Cancer stem cell	N.a.	N.a.
	Proliferation	Enhances proliferation in vivo an in vitro [79]	Enhanced invasion, proliferation and migration in two cell lines [79]
	Therapy	N.a.	N.a.
	Prognosis	Negative prognostic marker [97]	Negative prognostic marker [79]
	Future perspectives	Therapeutic relevance unclear, in vivo studies needed	Therapeutic relevance unclear, in vivo studies needed

N.a., no data available

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ISSN: 2050-7771

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