Table 2 S100A6’s biomarker role in tumor diseases

Thyroid Tumors

Tissue

Papillary carcinomas 10; follicular carcinomas 9; follicular adenomas 10

Discrimination between follicular thyroid tumors and papillary thyroid carcinoma

[87]

Meningiomas

Tissue

Benign meningiomas 39;

atypical meningiomas 24

Discriminatory between the benign and the atypical meningiomas

[88]

Cutaneous smooth

muscle neoplasms

Tissue

Pilar leiomyoma 22; angioleiomyoma 22; cutaneous leiomyosarcoma 22

Discriminatory between pilar leiomyoma, angioleiomyoma, and cutaneous leiomyosarcoma

[89]

Cholangiocarcinoma

Tissue

Cholangiocarcinoma 18; hepatocellular carcinoma 20

Differentiation cholangiocarcinoma from hepatocellular carcinoma

[90]

Lung squamous cell cancer

Tissue

Lung squamous cell cancer 177

Independent unfavorable prognostic factor for lung squamous cell cancer

[91]

Pulmonary adenocarcinoma

Tissue

Lung adenocarcinomas formalin-fixed and paraffinembedded 92; and frozen surgical specimens 6

Estimation of malignancy in adenocarcinoma

[92]

Thyroid carcinomas

Tissue

Thyroid neoplasms 141

Involved in the progression of papillary carcinoma

[93]

Cholangiocarcinom

Serum

Cholangiocarcinom 112; healthy controls 42

Biomarkers of poor prognosis

[94]

Cholangiocarcinoma

Tissue

/

Prognostic marker and potential therapeutic target

[95]

Thyroid carcinoma

Tissue

Thyroid carcinoma 118

Risk stratification regarding metastatic potential in papillary thyroid carcinoma

[96]

Pancreatic cancer

Pancreatic Juice

Pancreatic Juice 98

Early diagnosis and identification of high precancerous lesions

[97]

Pancreatic Cancer

Pancreatic juice and tissue

Pancreatic carcinoma 33; normal tissue samples 39

Diagnostic marker and therapeutic target

[98]

Bladder cancer

Serum

Bladder cancer 50; healthy controls 30

Early diagnostic marker

[99]

Cholangiocarcinoma

Tumor interstitial fluid

Cholangiocarcinoma 3; paired samples 3

Potential risk marker for screening of cholangiocarcinoma

[100]

Gastric cancer

Serum

Gastric cancer 103; healthy controls 72

Prognostic biomarker

[101]

Gastric cancer

Tissue

Gastric cancer 1; paired sample 1

Diagnostic marker

[102]

Non-small cell lung cancer

Serum

Non-small cell lung cancer 141; healthy controls 150

Diagnostic marker

[103]

Epithelial ovarian cancer

Serum

/

Detecting and/or monitoring ovarian cancer

[104]

Prostate cancer

Tissue

Benign 66; premalignant 10; malignant 66; metastatic prostate 5

Diagnostic marker

[105]