Fig. 5

Illustration of tissue-SELEX procedure [55]. (1) The library is incubated with the negative target and the unbound sequences are collected; (2) The unbound sequences are incubated with the positive target and the bound sequences ate collected; (3) The bound sequences are amplified by PCR amplification; (4) The dsDNA of PCR product is denatured and desalted for next round of SELEX.