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Fig. 5 | Biomarker Research

Fig. 5

From: ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade

Fig. 5

ICOS DNA methylation in melanoma and immune cells. A ICOS DNA methylation status [β-values] of seven CpG sites (CpG sites 1–7; Fig. 4A) in the melanoma TCGA cohort (N = 468; [24]) are shown. B ICOS DNA methylation status of CpG 2 in peripheral isolated leukocytes, comprising monocytes, B cells, CD4+ T cells, CD8+ T cells, and a granulocytes fraction (GEO accession number: GSE103541) and melanoma cell lines [30]. C Correlation between ICOS DNA methylation [β values] of CpG 4/5 with ICOS mRNA expression in melanoma cell lines. D ICOS DNA methylation status of CpG 4/5 in peripheral isolated leukocytes and melanoma cell lines. Bars represent median mRNA expression and methylation levels

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Biomarker Research

ISSN: 2050-7771

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