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Fig. 2 | Biomarker Research

Fig. 2

From: ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade

Fig. 2

ICOS protein expression in tonsillar, melanoma, and hepatic tissue. Representative immunohistochemical staining patterns in a (A) tonsil, (B-D, F) various melanomas, and hepatocytes (E). A In tonsillar tissue, lymphatic germinal centers stain strongly positive in proximity to the mantle zone. B Melanoma lung metastasis with heterogeneous ICOS expression in tumor cells ranging from absent to strong. C Cutaneous melanoma metastasis with ICOS+ and ICOS− TILs and moderately ICOS+ tumor cells. D Melanoma lymph node metastasis with negative lymphocytes and several strongly ICOS+ tumor cells. E Adjacent hepatocytes from a melanoma liver metastasis with moderate cytoplasmic and sporadic strong nuclear ICOS expression. F Melanoma with moderate cytoplasmic and sporadic strong nuclear ICOS expression

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Biomarker Research

ISSN: 2050-7771

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