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Fig. 1 | Biomarker Research

Fig. 1

From: ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade

Fig. 1

ICOS mRNA expression within melanomas. A ICOS mRNA expression levels in N = 468 melanomas obtained from the TCGA cohort. B Correlations (Spearman’s ρ) of ICOS mRNA expression with mRNA levels of the immune checkpoint genes PD-L1, PD-1, PD-L2, CTLA4, LAG3, and TIGIT, with interferon γ mRNA expression, and with mRNA signatures of immune cell infiltrates (CD8+ T cells: CD8A and CD8B, CD4+ T cells: CD4, B cells: CD19 and CD20, monocytes: CD14) in the TCGA and Liu et al. melanoma cohorts [24, 26]. C Single-cell RNA sequencing data obtained from Tirosh et al. [28] showing ICOS mRNA expression levels in T cells, B cells, macrophages, and CD45− cells. ***P < 0.001, NA: not available

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Biomarker Research

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