Fig. 4

Knockdown of SYT7 suppresses tumor growth in vivo. A The tumor growth curve was drawn based on the measurement of tumor volume at indicated time intervals. B The in vivo imaging was carried out to evaluate the tumor growth and (C) the bioluminescence intensity was scanned and used as a representative of tumor burden in mice xenograft models. D, E After sacrificing the mice at day 11 post injection, the xenografts were removed and subjected to weighing (D) and photographing (E). F The expression of Ki67 in sections of xenografts was detected by immunohistochemical staining (scale bar = 100 μm). Data were shown as mean ± SD. **P < 0.01, ***P < 0.001, based on a Student’s T-Test