Fig. 3
From: Emerging role of the RNA-editing enzyme ADAR1 in stem cell fate and function
Function of ADAR1 Zα. ADAR1 can promote A-to-I editing of endogenous Alu elements through the Zα structural domain to prevent dsRNA formation by reverse Alu repeat pairing. ADAR1, if absent, will induce ZBP1 activation, which in turn triggers caspase-8-dependent apoptosis and MLKL-mediated necroptosis of ADAR1-deficient cells. The small molecule compound CBL0137 can specifically induces Z-DNA conformation of genomic sequences, thus inducing ZBP1-dependent cell death