Fig. 2

Single-cell approaches utilized in disease research. Single-cell approaches are developed to profile the genome, epigenome, transcriptome/spatial transcriptome and proteome, and single-cell multi-omics approaches are built by combining different SCS methods, which have been widely used in disease research. SCS: single-cell sequencing; scRNA-seq: single-cell RNA sequencing; scDNA-seq: single-cell DNA sequencing; CNV: copy number variation; scATAC-seq: single-cell assay for transposase-accessible chromatin by sequencing; scChIP-seq: single-cell chromatin immunoprecipitation followed by sequencing; NGS: next generation sequencing; CITE-seq: cellular indexing of transcriptomes and epitopes by sequencing