Fig. 1From: Single-cell technologies in multiple myeloma: new insights into disease pathogenesis and translational implicationsUnresolved questions in the field of myeloma biology research. Studying MM biology in both myeloma intrinsic and extrinsic contexts will advance understanding of how the complex cross-talk between myeloma cells and surrounding non-cancer cells results in the successful growth of malignant subclones, with impacts on clonal revolution and resistance to therapies. MM: multiple myeloma;Â MMSCs: multiple myeloma stem cells; TME: tumor microenvironment; BM: bone marrowBack to article page