Table 2 The roles of m⁶A reader IGF2BPs across cancer types

Acute myelocytic leukemia

IGF2BP2

METTL3/14

MYC, GPT2, SLC1A5

–

Stability, translation

Glutamine metabolism, stem cell self-renewal

[83]

IGF2BP2

–

PRMT6

3’UTR

Stability

Stem cell maintenance

[53]

IGF2BP3

–

RCC2

CDS region

Stability

Proliferation, apoptosis resistance

[65]

T cell acute lymphoblastic leukemia

IGF2BP2

METTL3

NOTCH1

–

Stability

Survival, chemo-resistance

[70]

Nasopharyngeal carcinoma

IGF2BP2

WTAP

lncRNA DIAPH1-AS1

1–281 nt

Stability

Proliferation, metastasis

[44]

IGF2BP3

–

KPNA2

3’UTR

Stability

Proliferation, metastasis

[64]

Hypopharyngeal squamous cell carcinoma

IGF2BP2

ALKBH5

NFE2L2

3’UTR

Stability

Ferroptosis resistance

[54]

Laryngeal squamous cell carcinoma

IGF2BP3

RBM15

TMBIM6

3’UTR

Stability

Survival, metastasis

[60]

Papillary thyroid cancer

IGF2BP2

FTO

APOE

–

Stability

Glycolysis, proliferation

[82]

Breast cancer

IGF2BP3

METTL3

PD-L1

CDS region

Stability

Immune escape

[89]

Lung adenocarcinoma

IGF2BP1

METTL3/14

SRF

3’UTR

Stability

Growth, invasion

[41]

Gastric cancer

IGF2BP3

METTL3

HDGF

exon

Stability

Glycolysis, angiogenesis, proliferation, metastasis

[85]

IGF2BP3

ALKBH5

PKMYT1

CDS region

Stability

Invasion, migration

[63]

IGF2BP3

–

HIF1A

CDS region

Stability

Hypoxia-induced migration and angiogenesis

[86]

Hepatocellular carcinoma

IGF2BP1/2/3

METTL3/14

MYC

CRD

Stability, translation

Proliferation, metastasis

[5]

IGF2BP1

METTL3/14

SRF

3’UTR

Stability

Growth, invasion

[41]

IGF2BP1/3

METTL3

lnc-CTHCC

–

Stability

Proliferation, invasion

[58]

IGF2BP2

METTL14

lncRNA ARHGAP5-AS1

928 nt

Stability

Proliferation, metastasis

[50]

IGF2BP2

–

E2F3, E2F6

–

Stability

Stem cell self-renewal, metastasis

[51]

IGF2BP3

METTL3/ALKBH5

PDK4

5’UTR

Stability

Glycolysis, proliferation

[72]

Pancreatic cancer

IGF2BP2

–

lncRNA DANCR

664 nt

Stability

Proliferation, stemness-like property

[43]

IGF2BP2

METTL3

PLK1

3’UTR

Stability

Radio-resistance

[52]

Colorectal cancer

IGF2BP2

METTL3

SOX2

CDS region

Stability

Stemness maintenance, invasion, resistance to oxaliplatin

[69]

IGF2BP2

METTL3

HK2; SLC2A1

5′/3’UTR; 3’UTR

Stability

Glycolysis, proliferation

[79]

IGF2BP2

FTO

MTA1

CDS region

Stability

Metastasis

[45]

IGF2BP2

METTL3

HMGA1

3’UTR

Stability

EMT, proliferation, metastasis

[46]

IGF2BP2

METTL3

EphA2

3’UTR

Stability

Vasculogenic mimicry formation, proliferation, metastasis

[88]

IGF2BP2

–

lncRNA ZFAS1

843 nt

Stability

Glycolysis, proliferation, apoptosis resistance, invasion

[80]

IGF2BP2

–

MSX1, JARID2

–

Stability

Proliferation, apoptosis resistance, migration

[49]

IGF2BP3

–

CCND1

CDS

Stability

Cell cycle regulation, proliferation

[56]

IGF2BP3

–

VEGF

+ 2238 from the starting codon

Stability

Angiogenesis

[56]

IGF2BP3

METTL3

VEGFA

3’UTR

Stability

Vasculogenic mimicry formation, proliferation, metastasis

[88]

IGF2BP3

–

ABCB1

CDS

Stability

Resistance to ABCB1 substrates

[73]

IGF2BP3

METTL3

SLC2A1

3’UTR

Stability

Glycolysis, proliferation

[79]

Renal cell carcinoma

IGF2BP1/2/3

WTAP

S1PR3

near stop codon

Stability

Migration, proliferation

[67]

IGF2BP2

METLL3

ZNF677

CDS

Stability

Proliferation and apoptosis resistance

[48]

IGF2BP2

–

PPAT

–

Stability

Proliferation

[55]

Clear cell renal cell carcinoma

IGF2BP2

FTO

SIK2

CDS

Stability

Autophagy regulation

[84]

IGF2BP3

METTL3/14

CDK4

5’UTR

Stability

G1–S transition, proliferation, palbociclib resistance

[61]

IGF2BP3

METTL3/14

FN1; COL6A1; LAMA5

the exon 20; the exon 15 and 3’UTR; the exon 4

Stability

ECM deposition, metastasis

[61]

Prostate cancer

IGF2BP2

METTL3

lncRNA PCAT6

–

Stability

Proliferation, metastasis

[47]

Ovarian cancer

IGF2BP1

METTL3/14

SRF

3’UTR

Stability

Growth and invasion

[41]

Endometrial cancer

IGF2BP1

ALKBH5

PEG10

3’UTR

Stability

Cell cycle regulation, proliferation

[42]

Cervical cancer

IGF2BP1/2/3

METTL3/14

MYC

CRD

Stability, translation

Proliferation, metastasis

[5]

IGF2BP1

ALKBH5

FAAP20, ATRX

–

Stability

ROX-induced DNA damage repair

[66]

IGF2BP3

METTL3/ALKBH5

PDK4

5’UTR

Stability

Glycolysis, proliferation, resistance to doxorubicin

[72]

IGF2BP3

–

lncRNA KCNMB2-AS1

–

Stability

Proliferation, apoptotic resistance

[59]

IGF2BP3

METTL3

ACIN1

–

Stability

Proliferation, migration

[57]

Seminoma

IGF2BP1

METTL3

TFAP2C

–

Stability

Resistance to cisplatin

[68]

Osteosarcoma

IGF2BP2

METTL14

MN1

CDS

Stability and translation

Resistance to all-trans retinoic acid, stemness maintenance, proliferation, metastasis

[71]