Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential

Biomarker Research

Table 1 The roles of m⁶A readers on RNA metabolism

Reader	Function	Reference
IGF2BP1/2/3	promotes mRNA stability and translation	[5]
YTHDC1	promotes mRNA splicing and nuclear export	[27, 28]
YTHDC2	promotes mRNA translation initiation and instability	[29]
YTHDF1	enhances mRNA translation efficiency	[30]
YTHDF2	facilitates mRNA degradation	[31]
YTHDF3	affects mRNA translation and degradation through synergy with YTHDF1 and YTHDF2	[32]
eIF3	promotes mRNA cap-independent translation	[33]
METTL3	facilitates mRNA translation	[34]
FMR1	facilitates mRNA nuclear export, stability; competes with YTHDF1 for binding m⁶A sites to suppress translation	[35,36,37]
HNRNPC/G	mediates mRNA alternative splicing	[38, 39]
HNRNPA2B1	mediates primary microRNA processing and alternative splicing	[40]

Abbreviations: IGF2BP1/2/3, insulin-like growth factor-2 mRNA-binding protein 1/2/3; YTHDC1/2, YTH domain-containing protein 1/2; YTHDF1/2/3, YTH domain-containing family protein 1/2/3; eIF3, eukaryotic translation initiation factor 3; METTL3, methyltransferase-like 3; FMR1, fragile X messenger ribonucleoprotein 1; HNRNPC/G, heterogeneous nuclear ribonucleoprotein C/G; HNRNPA2B1, heterogeneous nuclear ribonucleoprotein A2B1

ISSN: 2050-7771