Table 2 The differentially expression of 14 serum amino acids, 15 bile acids, 6 classic tumor markers, and 10 plasma protein candidates among three groups

Ala

492.48(470.74 ~ 514.22)

508.45(486.29 ~ 530.60)

459.63(437.66 ~ 481.60)

0.310

0.002

0.037

Arg

119.39(113.92 ~ 124.87)

117.54(110.41 ~ 124.67)

113.34(106.91 ~ 119.76)

0.509

0.206

0.034

Cit

31.59(29.72 ~ 33.47)

38.46(35.87 ~ 41.05)

29.80(28.00 ~ 31.60)

< 0.001

< 0.001

0.112

Glu

232.27(221.71 ~ 242.84)

249.11(232.54 ~ 265.69)

232.32(218.96 ~ 245.68)

0.671

0.350

0.826

Gly

328.17(316.79 ~ 339.55)

349.13(332.02 ~ 366.23)

335.82(317.63 ~ 354.01)

0.369

0.259

0.780

His

102.51(99.16 ~ 105.86)

88.67(85.54 ~ 91.80)

83.71(80.55 ~ 86.88)

< 0.001

0.044

< 0.001

Leu

176.86(168.99 ~ 184.74)

173.87(166.79 ~ 180.95)

165.40(158.78 ~ 172.03)

0.309

0.153

0.022

Lys

280.72(268.26 ~ 293.18)

253.89(243.85 ~ 263.93)

242.94(232.12 ~ 253.76)

< 0.001

0.087

< 0.001

Orn

131.70(122.28 ~ 141.12)

152.05(143.48 ~ 160.61)

149.18(139.19 ~ 159.18)

< 0.001

0.464

0.005

Met

28.79(27.85 ~ 29.72)

30.28(28.96 ~ 31.60)

29.41(27.95 ~ 30.87)

0.315

0.364

0.936

Pro

198.68(186.09 ~ 211.27)

211.03(198.16 ~ 223.89)

195.82(185.94 ~ 205.70)

0.420

0.302

0.983

Phe

103.83(97.88 ~ 109.77)

106.27(101.71 ~ 110.82)

106.44(101.66 ~ 111.226)

0.320

0.614

0.590

Tyr

82.00(79.05 ~ 84.95)

77.60(74.42 ~ 80.77)

76.62(73.57 ~ 79.67)

0.047

0.662

0.013

Val

287.63(275.91 ~ 299.36)

307.66(296.48 ~ 318.84)

275.65(263.98 ~ 287.32)

0.015

< 0.001

0.153

CA

189.99(109.76 ~ 270.22)

493.07(273.37 ~ 712.78)

181.73(57.98 ~ 305.48)

0.011

0.001

0.508

DCA

432.71(351.24 ~ 514.18)

311.21(227.11 ~ 395.31)

139.50(85.36 ~ 193.64)

0.004

< 0.001

< 0.001

CDCA

1021.85(789.84 ~ 1253.87)

1360.35(918.62 ~ 1802.08)

789.31(539.28 ~ 1039.35)

0.953

0.006

0.005

UDCA

257.42(201.39 ~ 313.45)

190.33(139.66 ~ 241.00)

146.59(90.32 ~ 202.85)

< 0.001

0.002

< 0.001

LCA

24.70(20.19 ~ 29.22)

14.68(9.22 ~ 20.14)

11.09(8.84 ~ 13.35)

< 0.001

0.922

< 0.001

GCA

278.70(221.78 ~ 335.61)

423.39(258.99 ~ 587.79)

348.50(261.19 ~ 435.81)

0.958

0.942

0.870

GLCA

10.19(7.41 ~ 12.96)

7.94(5.46 ~ 10.42)

4.85(2.44 ~ 7.26)

0.033

0.052

< 0.001

GDCA

223.27(170.36 ~ 276.18)

417.09(239.57 ~ 594.62)

101.05(67.78 ~ 134.32)

0.593

< 0.001

< 0.001

GCDCA

871.95(742.94 ~ 1000.95)

1755.82(1386.13 ~ 2125.50)

1604.76(1325.65 ~ 1883.88)

< 0.001

0.914

< 0.001

GUDCA

268.93(217.68 ~ 320.19)

372.22(292.75 ~ 451.70)

428.74(250.72 ~ 606.76)

0.128

0.026

0.372

TCA

36.42(22.86 ~ 49.98)

60.60(29.70 ~ 91.51)

83.72(37.85 ~ 129.60)

0.758

0.166

0.077

TLCA

1.12(0.87 ~ 1.37)

1.43(0.71 ~ 2.14)

0.65(0.40 ~ 0.89)

0.106

0.006

< 0.001

TDCA

76.54(63.94 ~ 89.13)

82.53(49.93 ~ 115.12)

32.79(24.47 ~ 41.11)

< 0.001

0.001

< 0.001

TCDCA

105.18(86.12 ~ 124.24)

202.43(142.35 ~ 262.50)

290.78(205.57 ~ 375.99)

0.062

0.016

< 0.001

TUDCA

13.28(4.17 ~ 22.40)

8.20(6.22 ~ 10.18)

14.01(9.54 ~ 18.47)

0.674

0.596

0.544

CA125

14.12(12.56 ~ 15.68)

25.97(18.37 ~ 33.57)

21.56(17.16 ~ 25.97)

0.691

0.104

0.015

CA199

13.17(11.31 ~ 15.03)

27.76(17.94 ~ 37.58)

16.41(9.67 ~ 23.14)

0.019

0.004

0.627

CEA

1.96(1.68 ~ 2.24)

11.46(4.70 ~ 18.23)

2.89(2.37 ~ 3.41)

< 0.001

0.007

< 0.001

CYFRA211

2.18(1.96 ~ 2.40)

5.92(3.68 ~ 8.16)

3.06(2.65 ~ 3.48)

< 0.001

0.013

0.001

NSE

13.03(12.43 ~ 13.62)

12.91(11.95 ~ 13.86)

10.89(10.21 ~ 11.56)

0.107

< 0.001

< 0.001

SCC

1.41(1.26 ~ 1.56)

2.75(1.30 ~ 4.20)

1.41(1.12 ~ 1.70)

0.918

1.120

0.103

ApoA1

1.49(1.44 ~ 1.53)

1.36(1.32 ~ 1.41)

1.13(1.07 ~ 1.20)

< 0.001

< 0.001

< 0.001

ApoA2

25.76(25.12 ~ 26.40)

22.57(21.81 ~ 23.32)

18.30(17.24 ~ 19.37)

< 0.001

< 0.001

< 0.001

ApoB

0.84(0.81 ~ 0.87)

0.93(0.89 ~ 0.98)

0.83(0.78 ~ 0.87)

0.001

< 0.001

0.613

ApoC3

10.26(9.68 ~ 10.85)

10.30(9.58 ~ 11.02)

9.16(8.32 ~ 10.00)

0.719

0.011

0.003

C1INH

0.29(0.28 ~ 0.19)

0.32(0.31 ~ 0.33)

0.32(0.30 ~ 0.33)

< 0.001

0.661

0.001

C3

1.13(1.08 ~ 1.18)

1.26(1.21 ~ 1.32)

1.15(1.10 ~ 1.21)

< 0.001

0.001

0.960

C4

0.24(0.23 ~ 0.25)

0.28(0.26 ~ 0.29)

0.27(0.26 ~ 0.29)

0.005

0.955

0.006

FN

548.51(514.84 ~ 582.19)

435.43(401.12 ~ 469.74)

339.23(312.41 ~ 366.05)

< 0.001

< 0.001

< 0.001

Lpa

225.25(172.84 ~ 277.66)

298.87(242.88 ~ 354.87)

228.29(186.28 ~ 270.30)

0.060

0.047

0.928

Fg

2.66(2.55 ~ 2.77)

3.38(3.14 ~ 3.61)

3.93(3.62 ~ 4.25)

< 0.001

0.019

< 0.001