Fig. 2

Identifying lung cancer-specific differentially methylated regions. (a-b) Heatmap of the differentially methylated sites in lung cancer and benign pulmonary nodule tissues in training dataset (a) and validation dataset (b), contains 6604 hypermethylated and 2703 hypomethylated regions. (c) The region on the genes where the hypermethylated and hypomethylated sites are located. (d) The correlation between hypermethylated and hypomethylated DMRs and regulatory regions in genome.