Novel insights into the multifaceted roles of m6A-modified LncRNAs in cancers: biological functions and therapeutic applications

Table 1 Brief biological functions of lncRNA. What should be noticed is that some of these lncRNAs have multiple functions and mechanisms, this table just listed the functions and mechanisms mentioned in our review

LncRNAs	Functions	Mechanisms	References
XIST	Epigenetic modification	Recruit chromatin modification factors	[70, 71]
HOTAIR	Epigenetic modification	Recruit chromatin modification factors	[72]
LncPRESS1	Epigenetic modification	Interdict the recruitment of some chromatin modifiers	[73]
XIST	Transcriptional regulation	Modulate RNA polymerases	[74]
SLERT	Transcriptional regulation	Modulate RNA polymerases	[75]
Khps1	Transcriptional regulation	Form R-loops	[77]
1/2-sbsRNAs	Post-transcriptional regulation	Recruit degradation proteins	[78]
LncIRS1	Post-transcriptional regulation	Compete for microRNA binding	[79]
SINEUP- GFP, SINEUP-ΔAlu	Translational regulation	Modulate translational initiation complexes	[82]
CCAT2	Translational regulation	Interact with ribosomes and initiation factors	[83]
DILA1	Post-translational regulation	Inhibit the phosphorylation of proteins and block its subsequent degradation	[84]

ISSN: 2050-7771