Neutrophil extracellular traps primed intercellular communication in cancer progression as a promising therapeutic target

Table 1 The interplay between the tumor cell and NETs

Stimulator or Ligand of NETs	Receptors in the tumor cell	Regulated function	Type of Cancer	Reference
IL-8, G-CSF, GROα/β	-	tumor premetastatic niche formation	ovarian cancer	[17]
CXCR1/CXCR2 Agonists	-	immune-mediated cytotoxicity	solid malignancies	[28]
NE	TLR4	mitochondrial biogenesis and tumor growth	Colorectal cancer	[41]
HMGB1	TLR4	radioresistance	bladder cancer	[23]
NETs	TLR9	tumor proliferation, migration, and invasion	Colorectal cancer	[42]
NETs	TLR9	tumor proliferation and metastasis	Diffuse large B-cell lymphoma	[21]
NETs	TLR4/9	tumor metastasis	Hepatic cell carcinoma	[43]
NET-DNA complex	CCDC25	tumor cell motility and tumor metastasis	Breast cancer	[11]
NETs	integrin α5β1, αvβ3, and αvβ5	tumor cell adhesion	Pan-cancer	[46]
NETs	integrin β1	tumor cell adhesion	Lung cell carcinoma	[29]
NETs-cleaved laminin-111	integrin a3β1	awaken dormant tumor cell	Breast cancer	[10]

ISSN: 2050-7771