Fig. 1
From: Retinal determination gene networks: from biological functions to therapeutic strategies
The Role of RDGN in the progression of breast cancer. The functional balance of DACH1 and SIX1/EYA keeps the homeostasis of luminal cell proliferation and apoptosis, which maintains the stability of the luminal structure. The abnormal expression of DACH1 and SIX/EYA caused a disorder of physiological functions. Subsequently, the luminal cells may undergo hyperproliferation, and transform to form ductal cancer in situ (DCIS). Then some cells acquire epithelial-mesenchymal transition (EMT) and trigger tumor metastasis by invading the basement membrane and entering blood vessels. “↓” means downregulated function, while “↑” means up-regulated functions. (The role of RDGN in the progression of RDGN was adapted from Fig. 1 in [16].)