Fig. 1

The effects of diets on hepatic transcriptomes of WT and FXR KO mice with different ages. A Principal component analyses of liver transcriptomes of 5-, 10-, and 15-month-old WT and FXR KO mice fed with either a CD or WD since weaning. B Venn diagrams show the numbers of genes differentially expressed due to diet (WD vs. CD) intake in WT or FXR KO mice. C Pathway enrichment analyses for up and downregulated genes affected by differential diet intake using Metascape. The top 20 pathways are shown (adjusted p value < 0.05). WD-regulated pathways shared by WT and FXR KO mice are in purple. The numbers of differentially expressed genes in each pathway are shown in the bars