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Table 1 Radiomic features significantly correlated with characteristics of CD8+ T cell exhaustion selected through LASSO regression

From: PET-based radiomics visualizes tumor-infiltrating CD8 T cell exhaustion to optimize radiotherapy/immunotherapy combination in mouse models of lung cancer

 

CT

PET

 

Feature

Coefficient

Feature

Coefficient

Early Tex proportion among CD8+ T cells

SurfaceAreaDensity

0.291541

Contrast

0.003785638

Homogeneity2

-3.455633658

Kurtosis

(Intensity Histogram)

1.696675694

Kurtosis (Intensity Direct)

-0.482919952

Terminal Tex proportion among CD8+ T cells

/

/

InverseVariance

-124.62754

E/T

/

/

Homogeneity2

-1.09342672

Kurtosis

(Intensity Histogram)

0.26680888

Kurtosis (Intensity Direct)

-0.02380306

MFI of PD-1 expression on CD8+ T cells

Compactness2

1069.80865

InverseVariance

-2068.013

ConvexHullVolume3D

-32.8878

  1. Tex exhausted T cells
  2. E/T the ratio of early to terminal Tex
  3. MFI mean fluorescence intensity