Table 2 The function of YTHDF1 in human cancers
From: The function and clinical implication of YTHDF1 in the human system development and cancer
Cancer Type | Regulation | Target gene | Roles | Function | References |
|---|---|---|---|---|---|
Esophageal cancer | Up | HK2 | Translation | Promotes cell proliferation | [73] |
Esophageal cancer | Up | ERBB2 | Stabilization | Promotes cell proliferation/migration | [74] |
Gastric cancer | Up | FZD7 | Translation | Promotes cell proliferation/migration | [23] |
Gastric cancer | Up | USP14 | Translation | Promotes cell proliferation/migration/EMT | [75] |
Gastric cancer | Up | PARP1 | Translation | Promotes oxaliplatin resistance | [76] |
Colorectal cancer | Up | ARHGEF2 | Translation | Promotes EMT | [77] |
Gastric cancer | Up | GLS1 | Translation | Promotes cell proliferation/migration | [78] |
Gastric cancer | Up | ANKLE1 | Translation | Promotes cell proliferation | [79] |
Liver cancer | Up | Snail | Translation | Promotes EMT | [80] |
Liver cancer | Up | FZD5 | Translation | Promotes cell proliferation/migration | [81] |
Liver cancer | Up | ATG2A | Translation | Promotes autophagy, growth, and metastasis | [55] |
Lung cancer | Up | CDK2 | Translation | Promotes cell proliferation | [22] |
Lung cancer | Up | YAP | Translation | Promotes cell proliferation/migration/EMT | [82] |
Lung cancer | Up | THOR | Stabilization | Promotes cell proliferation | [83] |
Lung cancer | Up | TGFβR2 | Translation | Promotes EMT | [84] |
Lung cancer | Up | PRPF6 | Translation | Promotes cell proliferation/migration | [85] |
Bladder cancer | Up | ITGA6 | Translation | Promotes cell proliferation/migration | [50] |
Bladder cancer | Up | CDCP1 | Translation | Promotes cell proliferation/migration | [86] |
Ovarian cancer | Up | EIF3C | Translation | Promotes cell proliferation | [87] |
Ovarian cancer | Up | TRIM29 | Translation | Promotes cisplatin-resistance | [88] |
Breast cancer | Up | PKM2 | Translation | Promotes glycolysis | [89] |
Breast cancer | Up | FOXM1 | Translation | Promotes cell proliferation/migration | [90] |
Osteosarcoma | Up | CNOT7 | Translation | Promotes cell proliferation/migration/EMT | [91] |
Osteosarcoma | Up | YAP | Translation | Promotes cell proliferation/migration/EMT | [92] |