Table 1 The function of YTHDF1 in normal system development
From: The function and clinical implication of YTHDF1 in the human system development and cancer
Embryonic/stem cell | Target gene | Functions | References |
|---|---|---|---|
JAK2 | Promotes pluripotency of embryonic stem cells | [49] | |
None | Promotes cardiomyocytes differentiation | [62] | |
TEAD1 | Promotes intestinal stemness | [63] | |
TCF7L2/TCF4 | Promotes intestinal stemness | [64] | |
ZNF839 | Promotes bone marrow mesenchymal stem cells | [65] | |
MyHC/MyoD | Promotes Myogenic differentiation | [66] | |
MAGED1 | Promotes PASMC proliferation | [67] | |
Nervous system | None | Spatial learning and memory | [68] |
None | Promotes learning and memory | [25] | |
robo3.1 | Promotes pre-crossing axon guidance | [46] | |
Dvl1/Wnt5a | Promotes axon growth | [69] | |
SCG10 | Promotes lesion-induced | [70] | |
Immune system | HMGB1/RAGE | Promotes immune paralysis | [71] |
SOCS3 | Promotes anti-inflammatory | [72] | |
Cathepsins | Promotes cross-presentation of tumor antigen | [24] |