Fig. 6
miR-124-3p inhibits tumor growth and metastasis in vivo. a Representative images of xenograft tumors derived from A549 cells expressing mimic NC, miR-124-3p mimic or miR-124-3p mimic + oe-Rab27a implanted in nude mice. b Quantification of xenograft tumor volume at different days after tumor volume reached 100 mm3 c Weight of tumors harvested from animals after 22 days of monitoring. d Images of immunohistochemical staining for Ki67, E-cadherin and Rab27a in xenograft tumors. e Bioluminescence images of lung metastases generated with A549 cells expressing mimic NC, miR-124-3p mimic or miR-124-3p mimic + oe Rab27a. f Quantification of bioluminescence from the lung metastases. g Concentration of exosomes in plasma of nude mice implanted with modified A549 cells. Data are shown as the mean ± SD. *P < 0.01, **P < 0.001, ***P < 0.0001, and ****P < 0.00001