Cervical cancer heterogeneity: a constant battle against viruses and drugs

Sun, Qian; Wang, Liangliang; Zhang, Cong; Hong, Zhenya; Han, Zhiqiang

doi:10.1186/s40364-022-00428-7

Biomarker Research

Table 1 Summary of high-frequency disrupted genes by HPV integration in cervical cancer

From: Cervical cancer heterogeneity: a constant battle against viruses and drugs

Gene	Integrations reported	Official full name	Gene ID	Location	Reference
MACROD2	13	Mono-ADP ribosylhydrolase 2	140733	20p12.1	[39,40,41,42,43,44]
FHIT	11	Fragile histidine triad diadenosine triphosphatase	2272	3p14.2	[39, 41, 42]
POU5F1B	11	POU class 5 homeobox 1B	5462	8q24.21	[41,42,43]
LRP1B	10	LDL receptor related protein 1B	53353	2q22.1	[39, 42]
RAD51B	10	RAD51 paralog B	5890	14q24.1	[39, 40, 44]
KLF12	9	Kruppel like factor 12	11278	13q22.1	[41, 42]
KLF5	9	Kruppel like factor 5	688	13q22.1	[39, 41, 42]
HMGA2	7	High mobility group AT-hook 2	8091	12q14.3	[42]
ERBB2	7	Erb-b2 receptor tyrosine kinase 2	2064	17q21.31	[40, 41, 44]
DMD	7	Dystrophin	1756	Xp21.2-p21.1	[39, 42, 44]
MAPK10	6	Mitogen-activated protein kinase 10	5602	4q21.3	[39, 42, 43]
MYC	6	MYC proto-oncogene, bHLH transcription factor	4609	8q24.21	[39, 40, 42, 44]
DLG2	6	Discs large MAGUK scaffold protein 2	1740	11q14.1	[39, 42]
LEPREL1	6	Prolyl 3-hydroxylase 2	55214	3q28	[42, 44]
CASC8^a	9	Cancer susceptibility 8	727677	8q24.21	[39, 40, 44]
TP63	6	Tumor protein p63	8626	3q28	[39, 40, 42, 44]
ENTPD5	5	Ectonucleoside triphosphate diphosphohydrolase 5	957	14q24.3	[39]
PARD3B	5	Par-3 family cell polarity regulator beta	117583	2q33.3	[41, 42]
PVT1^a	5	Pvt1 oncogene	5820	8q24.21	[44]
SEMA3D	5	Semaphorin 3D	223117	7q21.11	[42]
ZFAND3	5	Zinc finger AN1-type containing 3	60685	6p21.2	[39, 42]
FOXP2	5	Forkhead box P2	93986	7q31.1	[42, 44]
PAKN	5	Parkin RBR E3 ubiquitin protein ligase	5071	6q26	[42, 44]
TAFA5	5	TAFA chemokine like family member 5	25817	22q13.32	[39, 42, 44]
TPRG1	5	Tumor protein p63 regulated 1	285386	3q28	[39, 42, 43]
ARAP2	4	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	116984	4p14	[39, 42]
BBS9	4	Bardet-Biedl syndrome 9	27242	7p14.3	[39, 42]
CHL1	4	Cell adhesion molecule L1 like	10752	3p26.3	[39, 42]
CNTNAP2	4	Contactin associated protein 2	26047	7q35-q36.1	[39, 42]
AGTR2,	4	Angiotensin II receptor type 2	186	Xq23	[42]
CADM2	4	Cell adhesion molecule 2	253559	3p12.1	[42]
CDH7	4	Cadherin 7	1005	18q22.1	[42]
CPNE8	4	Copine 8	144402	12q12	[42]
DCC	4	DCC netrin 1 receptor	1630	18q21.2	[42]
DUSP6	4	Dual specificity phosphatase 6	1848	12q21.33	[42]
EPHA6	4	EPH receptor A6	285220	3q11.2	[42]
HS3ST4	4	Heparan sulfate-glucosamine 3-sulfotransferase 4	9951	16p12.1	[42]
TEKT4P2^a	4	Tektin 4 pseudogene 2	100132288	21p11.2	[42]
MSX2	4	Msh homeobox 2	4488	5q35.2	[42]
NEK11	4	NIMA related kinase 11	79,859	3q22.1	[42]
PCDH15	4	Protocadherin related 15	65217	10q21.1	[42]
PLS3	4	Plastin 3	5358	Xq23	[42]
PRDM9	4	PR/SET domain 9	56979	5p14.2	[42]
ZNF33B	4	Zinc finger protein 33B	7582	10q11.21	[42]
IGF1	4	Insulin like growth factor 1	3479	12q23.2	[42, 44]
CNTNAP5	4	Contactin associated protein family member 5	129684	2q14.3	[39, 42]
ERC2	4	ELKS/RAB6-interacting/CAST family member 2	26059	3p14.3	[39, 42]
FGF13	4	Fibroblast growth factor 13	2258	Xq26.3-q27.1	[39, 42]
LINGO2	4	Leucine rich repeat and Ig domain containing 2	158038	9p21.2-p21.1	[39, 42]
RPRD2	4	Regulation of nuclear pre-mrna domain containing 2	23248	1q21.2	[39]
MYO16	4	Myosin XVI	23026	13q33.3	[39, 42]
PTPRN2	4	Protein tyrosine phosphatase receptor type N2	5799	7q36.3	[39, 42]
RELN	4	Reelin	5649	7q22.1	[39, 42]
RGS6	4	Regulator of G protein signaling 6	9628	14q24.2	[39, 42]
SPOCK3	4	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3	50859	4q32.3	[39, 42]
ZFAT	4	Zinc finger and AT-hook domain containing	57623	8q24.22	[39, 42]
CSMD3	4	CUB and Sushi multiple domains 3	114788	8q23.3	[39, 41, 42]
ERBB4	4	Erb-b2 receptor tyrosine kinase 4	2066	2q34	[39, 41, 42]
CA10	4	Carbonic anhydrase 10	56934	17q21.33-q22	[39, 42]
PDE4D	4	Phosphodiesterase 4D	5144	5q11.2-q12.1	[39, 42]
NLGN1	4	Neuroligin 1	22871	3q26.31	[39, 42]
PROX1	4	Prospero homeobox 1	5629	1q32.3	[40, 42]
ZMAT4	4	Zinc finger matrin-type 4	79698	8p11.21	[39, 42]
TNIK	4	TRAF2 and NCK interacting kinase	23043	3q26.2-q26.31	[39, 40]

^aRepresent the gene type is ncRNA or pseudo, others are protein coding genes

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