Fig. 4
From: CAR-T cell potency: from structural elements to vector backbone components
A schematic picture of costimulatory molecules commonly used in CAR construct and their ligands on antigen presenting cells (a), Three CAR configurations (19BBz-CD80, 1928z-41BBL, and 19z1-CD80-41BBL) in Zhao’s study that are coupled with complementary costimulatory ligands (b). The 19BBz-CD80 and 1928z-41BBL are two 2nd-generation CARs coupled with CD80 and 41BBL, respectively. The 19z1-CD80-41BBL is a 1st-generation CAR that combined with both CD80 and 41BBL