Table 1 The impacts of lactate and acidification on immune cells in the TME
From: Impact of NSCLC metabolic remodeling on immunotherapy effectiveness
Immune cells | Effects |
|---|---|
TADCs | Inhibition monocyte activation [64] |
Inhibition antigen presentation [65] | |
MDSCs | Immunosuppressive microenvironment [66] |
Cancer aggressiveness [66] | |
NK cells | Inhibition of effector functions [66] |
TAMs | |
Treg cells | Increase in Treg proliferation [76] |
Enhancement of immunosuppressive effect [76] | |
CD8 + T cells | Inhibition of effector functions [74] |