Table 1 The target genes, biological functions and mechanisms of RNA m6A methyltransferases, demethylases, and binding proteins in hematopoietic malignancies

METTL3

MYC, BCL2, PTEN

Promotes translation of MYC, BCL2, PTEN and inhibits pAKT pathway

Promotes cell proliferation and colony formation, inhibits differentiation and apoptosis

[100]

SP1

Promotes translation of SP1

Promotes cell proliferation and inhibits differentiation

[101]

notch1a

decreases stability of notch1a mRNA and inhibits Noctch signaling pathway

Promotes HSCs generation through the endothelial-to-hematopoietic transition (EHT)

[102]

No study

No study

Maintains HSCs in a quiescent state

[103]

METTL14

MYB, MYC

Increases mRNA stability and promotes translation of MYB, MYC

Promotes cell proliferation and colony formation, inhibits differentiation and apoptosis

[104]

WTAP

MYC

Decreases mRNA stability

Promotes cell proliferation, colony formation and chemoresistance, inhibits differentiation

[105]

No study

Hsp90 maintains the protein stability of WTAP

Promotes cell proliferation, colony formation and chemoresistance, inhibits differentiation

[106]

FTO

MYC, CEBPA

Increases mRNA stability

Promotes cell proliferation

[89]

ASB2, RARA

Decreases mRNA stability

Promotes cell proliferation, colony formation and chemoresistance, inhibits differentiation and apoptosis

[107]

PFKP, LDHB

Increases mRNA stability

Promotes aerobic glycolysis

[108]

MERTK, BCL2

Increases mRNA stability

Promotes cell proliferation and drug resistance

[109]

LILRB4

Increases mRNA stability

Promotes decitabine-induced immune evasion and makes AML cells more resistant to T cell cytotoxicity

[110]

ALKBH5

AXL

Increases mRNA stability

Promotes cell proliferation and colony formation, inhibits differentiation and apoptosis

[111]

TACC3

Increases mRNA stability

Promotes cell proliferation and colony formation, inhibits apotosis

[112]

YTHDF2

TNFR2

Decreases mRNA stability

Promotes cell proliferation and inhibits apotosis

[113]

Wnt target genes

Promotes mRNAs degradation of Wnt target genes

1s in a quiescent state

[103]

Tal1

Promotes mRNAs degradation of key transcription factors

Maintains HSCs in a quiescent state

[114]

YTHDC1

MCM4

Promotes DNA replication

Promotes cell proliferation and inhibits apotosis

[115]

IGF2BP1

IGF2B3

ALDH1A1, HOXB4, MYB

RCC2

Increases the expression

Increases mRNA stability

Promotes cell proliferation, colony formation and chemoresistance, inhibits differentiation

Promotes cell proliferation and inhibits apotosis

[116, 117]

RBM15

Notch pathway

promotes Notch-induced HES1 transcription

Inhibits differentiation

[118]