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Table 1 The target genes, biological functions and mechanisms of RNA m6A methyltransferases, demethylases, and binding proteins in hematopoietic malignancies

From: Physio-pathological effects of N6-methyladenosine and its therapeutic implications in leukemia

Regulator Target genes Mechanisms Biological functions Reference
METTL3 MYC, BCL2, PTEN Promotes translation of MYC, BCL2, PTEN and inhibits pAKT pathway Promotes cell proliferation and colony formation, inhibits differentiation and apoptosis [100]
  SP1 Promotes translation of SP1 Promotes cell proliferation and inhibits differentiation [101]
  notch1a decreases stability of notch1a mRNA and inhibits Noctch signaling pathway Promotes HSCs generation through the endothelial-to-hematopoietic transition (EHT) [102]
  No study No study Maintains HSCs in a quiescent state [103]
METTL14 MYB, MYC Increases mRNA stability and promotes translation of MYB, MYC Promotes cell proliferation and colony formation, inhibits differentiation and apoptosis [104]
WTAP MYC Decreases mRNA stability Promotes cell proliferation, colony formation and chemoresistance, inhibits differentiation [105]
  No study Hsp90 maintains the protein stability of WTAP Promotes cell proliferation, colony formation and chemoresistance, inhibits differentiation [106]
FTO MYC, CEBPA Increases mRNA stability Promotes cell proliferation [89]
  ASB2, RARA Decreases mRNA stability Promotes cell proliferation, colony formation and chemoresistance, inhibits differentiation and apoptosis [107]
  PFKP, LDHB Increases mRNA stability Promotes aerobic glycolysis [108]
  MERTK, BCL2 Increases mRNA stability Promotes cell proliferation and drug resistance [109]
  LILRB4 Increases mRNA stability Promotes decitabine-induced immune evasion and makes AML cells more resistant to T cell cytotoxicity [110]
ALKBH5 AXL Increases mRNA stability Promotes cell proliferation and colony formation, inhibits differentiation and apoptosis [111]
  TACC3 Increases mRNA stability Promotes cell proliferation and colony formation, inhibits apotosis [112]
YTHDF2 TNFR2 Decreases mRNA stability Promotes cell proliferation and inhibits apotosis [113]
  Wnt target genes Promotes mRNAs degradation of Wnt target genes 1s in a quiescent state [103]
  Tal1 Promotes mRNAs degradation of key transcription factors Maintains HSCs in a quiescent state [114]
YTHDC1 MCM4 Promotes DNA replication Promotes cell proliferation and inhibits apotosis [115]
IGF2BP1
IGF2B3
ALDH1A1, HOXB4, MYB
RCC2
Increases the expression
Increases mRNA stability
Promotes cell proliferation, colony formation and chemoresistance, inhibits differentiation
Promotes cell proliferation and inhibits apotosis
[116, 117]
RBM15 Notch pathway promotes Notch-induced HES1 transcription Inhibits differentiation [118]