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Fig. 3 | Biomarker Research

Fig. 3

From: Selective isolation of extracellular vesicles from minimally processed human plasma as a translational strategy for liquid biopsies

Fig. 3

IP efficiency is dependent on EV surface properties, complex matrix components and interactions between both. (A) Fluorescence S/N ratios were assessed on triple-coated beads upon the IP of 22RV1-NIR and HT29-CFSE spiked in either PBS-BSA or plasma (donor 6). Average recovery (S/N) differences between the two matrices were reported in percentage. (B) CFSE-labelled EVs were spiked in plasma (donor 7) or in PBS-BSA and recovered using triple-coated beads. Average recovery (S/N) differences between the two matrices were reported in percentage. (C) CFSE-labelled HEK293 (blue) and HT29 EVs (orange) were spiked in plasma samples of 3 different donors and recovered using triple-coated beads. CFSE S/N on beads was directly proportional to the amount of captured spike

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Biomarker Research

ISSN: 2050-7771

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