Table 2 The correlations between VISTA and immune cells
From: IGSF11 and VISTA: a pair of promising immune checkpoints in tumor immunotherapy
Condition | Immune cells | Correlations with VISTA | PMID |
|---|---|---|---|
Soft tissue sarcomas | TIL | High expression of VISTA is associated with higher level of TIL | 35,205,752 |
Pancreatic cancer | CD68 + macrophages | High expression of VISTA on CD68 + macrophages | 30,635,425 |
CD8 + T cells | Inhibit the production of TNF-α and IFN-γ | ||
Inhibit the function of CD8 + T cells | |||
Pancreatic cancer | CD19 + B cells | high level of VISTA is positively associated with CD19 + B cells, CD3 + T cells and CD68 + macrophages | 33,237,432 |
CD3 + T cells | |||
CD68 + macrophages | |||
Melanoma | Treg | The block of VISTA reduces the number of tumor specific Foxp3 + CD4 + Treg cells, the presence of activated dendritic cells and MDSCs, increases the number of TILs, and promotes the function of T cells | 24,691,994 |
MDSCs | |||
DCs | |||
TIL | |||
Ovarian and endometrial cancer | CD8 + T cells | VISTA can significantly inhibit T cell proliferation and cytokine IFN-γ production | 30,127,950 |
30,382,166 | |||
NK/T cell lymphoma | CD8 + TILs | High expression of VISTA is correlated with the increase of CD8 + TILs and Foxp3 + TILs | 33,889,438 |
Foxp3 + TILs | |||
NSCLC | TIL | High expression of VISTA increases the count of tumor-infiltrating lymphocytes, tumor associated macrophages, effector T cells | 30,746,169 |
Tumor associated macrophages | |||
Effector T cells | |||
Melanoma | MDSCs | VISTA is expressed on CD33 + myeloid cells and positively associated with the expression of CD33 | 32,873,829 |
VISTA-mediated anti-tumor immunity | Macrophages | The absence of VISTA promotes the production of proinflammatory cytokines of TLR-mediated in peritoneal macrophages | 31,340,983 |
MDSCs subsets | |||
DCs subsets | VISTA regulates the effector function and accumulation of tumor-associated myeloid cDCs, inflammatory DCs, CD103 + DCs, PMN-MDSCs and M-MDSCs | ||
Allergic asthma | Th2 | VISTA involves in the generation of Th2 cells and related antibody production | 29,267,882 |
Maintaining naïve T cell quiescence and tolerance | Naïve CD4 + T cells | The absence of VISTA enhance the response of CD44hi CD4 + memory-like T cells to TCR and cytokine stimulation | 31,949,051 |
Antigen-specific T cells | The block of VISTA induces the tolerance reduction of antigen-specific T cells | ||
Giant cell arteritis | Th1 | The block of VISTA promotes the differentiation of Th1 and Th17 cells | 31,379,838 |
Th17 | |||
Anti-VISTA mAbs research | Monocytes | The administration of anti-VISTA mAb induces the activation of monocytes | 34,106,206 |
Collagen antibody-induced arthritis | Macrophages | VISTA regulates the response of macrophages to immune complexes | 29,216,931 |
Glomerulonephritis | Neutrophil | The block of VISTA inhibits the activation of neutrophil | 32,586,651 |