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Fig. 1 | Biomarker Research

Fig. 1

From: Roles of circRNAs in hematological malignancies

Fig. 1

Biosynthesis of circRNAs. CircRNAs can be directly generated by back-splicing; Intron-driven circularization can be inhibited by RNA helicase DHX9; Lariat-driven circularization generates a lariat structure. Spliceosome can splice to generate circRNAs and lariat-introns RNAs. Lariat-introns RNAs can be degraded, but some lariat-introns RNAs can escape degradation to form ciRNAs

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Biomarker Research

ISSN: 2050-7771

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