Table 2 Yap-associated proteins involved in LCSC related mechanisms
From: The role of YAP1 in liver cancer stem cells: proven and potential mechanisms
Proteins | Mechanism |
|---|---|
LATS1/2 MOBs | Phosphorylating YAP1 |
14–3-3 protein | Leading to cytosolic sequestration of YAP1 |
TEAD | Interacting with YAP1 and activating downstream gene expression |
β-Trcp | Mediating ubiquitination and degradation of YAP1 |
SMAD | P-YAP1/SMAD interaction inhibiting SMAD3 phosphoactivation |
OGT | Mediating O-GlcNAcylation of YAP1 |
ARID1A/SWI/SNF | Binding to YAP1 and inhibiting its interaction with TEAD |
β-catenin | Forming β-catenin destruction complex with YAP1 |