Fig. 2

Signaling pathways involved in YAP1-related LCSCs. Several signaling pathways listed above have been found to be involved in the promotion of YAP1-induced LCSCs. Among them, the Notch pathway and IGF pathway are affected by YAP1 in turn by positive feedback loops. The interactions between these pathways also play roles in YAP1-induced LCSCs, and the Wnt pathway suppresses the YAP1-Notch positive feedback loop and upstream components in the Hippo cascade