Table 3 Tumor Histology, Best Response, and Biomarkers
From: Pembrolizumab activity in patients with Fanconi anemia repair pathway competent and deficient tumors
Tumor Histology | FATSI | PD-L1 Score | TMB Score | Response |
|---|---|---|---|---|
Ovarian (Papillary Serous) | Negative | N/A | N/A | PR |
Esophagus Squamous | Negative | N/A | Intermediate | SD |
Endometrial | Negative | Negative|0% | 9 muts/Mb | CR |
Endometrial | Negative | Negative|0% | 7 muts/Mb | SD |
Endometrial | Negative | N/A | N/A | PR |
Adenoid Cystic Carcinoma | Negative | N/A | 7 muts/Mb | PD |
Endometrium | Negative | N/A | N/A | CR |
Vaginal | Negative | N/A | N/A | PD |
Endometrium | Negative | N/A | N/A | PR |
Colon | Negative | Negative|0% | 9 muts/Mb | PD |
Endometrial | Negative | Negative|0% | 7 muts/Mb | PD |
Endometrial | Negative | N/A | 5 muts/Mb | PD |
Endometrial | Negative | Negative|0% | 14 muts/Mb | SD |
Endometrial | Negative | N/A | N/A | SD |
Endometrial | Negative | CPS >/= 1 | N/A | PR |
Endometrial | Negative | Negative|0% | 6 muts/Mb | PD |
Colon | Positive | N/A | NA | PD |
Thymic | Positive | N/A | Low/3.5 | SD |
Ovarian | Positive | N/A | N/A | PD |
Ovarian | Positive | N/A | N/A | PD |
Fallopian Tube | Positive | N/A | N/A | PD |
Cervical Squamous | Positive | N/A | High | PR |
Pancreatic | Positive | N/A | N/A | PD |
Endometrial Carcinosarcoma | Positive | Negative | Low/4 | PD |
Cervical Squamous | Positive | N/A | N/A | SD |
Fallopian tube | Positive | N/A | N/A | SD |
Pancreatic | Positive | N/A | Intermediate | PD |
Endometrial | Positive | Negative | Low/6 | PD |
Ovarian (Serous) | Positive | Negative | Low/4 | PD |
Ovarian | Positive | N/A | N/A | SD |
Breast | Positive | N/A | 7.9 muts/Mb | SD |
Ovarian (Serous) | Positive | N/A | 10 muts/Mb | PD |
Mullerian Remnant Papillary Serous | Positive | Negative|0% | 6 muts/Mb | SD |
Ovarian | Positive | N/A | N/A | NE |
Neuroendocrine Colorectal | Positive | N/A | N/A | PD |
Ovarian | Positive | N/A | N/A | PD |
Ovarian | Positive | Negative|1+, 2% | N/A | PD |
Tonsil | Positive | N/A | N/A | SD |
Ileum | Positive | N/A | N/A | PR |
Uterine Sarcoma | Positive | Positive | 2+  95% | 4 muts/Mb | SD |
Vulvar | Positive | CPS < 1 0 | 4.2 muts/Mb | SD |
Vaginal | Positive | N/A | N/A | PD |
Ovarian | Positive | 0%, Negative | 4 muts/Mb | PD |
Endometrial | Positive | N/A | N/A | PD |
Ovarian | Positive | N/A | N/A | PD |
Endometrial | Positive | N/A | N/A | SD |
Endometrial | Positive | N/A | N/A | PD |
Endometrial | Positive | CPS 3; 0% in older test | 4 muts/Mb | PD |
Endometrial Carcinosarcoma | Positive | Negative|0% | 8 muts/Mb | PD |