Intratumor microbiome in cancer progression: current developments, challenges and future trends

Liu, Jinyan; Zhang, Yi

doi:10.1186/s40364-022-00381-5

Biomarker Research

Table 1 Summary of intratumor bacteria in cancerous tissues and their roles in oncogenesis, progression, and prognosis in cancers

From: Intratumor microbiome in cancer progression: current developments, challenges and future trends

Genus	Status	Cancer	Samples	Role	Mechanism	Refs
Bacteria
Thermus and Ralstonia	Dysbiosis	Lung	Adenocarcinoma and squamous cell carcinoma	Cancer histology	NT
Legionella	Enriched		Primary and metastatic lung tumor tissues	Oncogenesis metastasis	NT	[37]
Acidovorax	Enriched		Lung cancer tissues with or without TP53 mutation	Linked with TP53 mutation		[38]
Staphylococcus	Decreased		Tissues from lung cancer patients with unilateral lobar masses and healthy controls			[39]
Anaerococcus, Caulobacter, Streptococcus, and Propionibacterium	Decreased	Breast	Tissues from Breast cancer patients, predisposed to breast cancer, and healthy controls	Negatively correlated with oncogenic immune features; positively associated with T-cell activation-related genes		[40]
Bacteroidetes and Firmicutes	Lower ratio		Benign and breast cancer			[41]
Fusobacterium nucleatum	Enriched		Benign and breast cancer	Poor prognosis	Oncogenesis and suppressed immune response	[42]
Bacteroides fragilis	Enriched			Cancer progression	BFT drives epithelial hyperplasia in the mammary gland	[43]
Lactobacillus fermentum	Enriched	Esophageal	Tissues from esophageal cancer patients and healthy controls	Cancer screen	NT	[44]
Campylobacter species	Enriched		Esophageal adenocarcinoma and control tissues	Prognosis	NT	[45]
F. nucleatum	Enriched		Esophageal cancer and normal tissues	Prognosis	NT	[46]
Bacteroidetes/Fusobacteria/Spirochaetes	Decreased		Esophageal cancer and normal tissues		NT	[47]
Actinobacteria	Enriched		Esophageal cancer and normal tissues		NT	[48]
P. gingivalis	Enriched		Esophageal tissues from ESCC patients and normal controls	Progression and prognosis	NT	[49]
Fusobacterium nucleatum	Enriched		Resected ESCC samples	Chemoresistance	NT	[50]
Fusobacterium and less Streptococcus	Dysbiosis		ESCC tumor tissues and normal tissues	Oncogenesis	NT	[51]
H. pylori	Enriched	Gastric	Gastric cancer and normal tissues	Oncogenesis	Promote p53 degradation and immune evasion	[52,53,54,55]
E.coli, butyrate-producing bacterium SM4/1, Oscillatoria	Enriched	Bladder	Tumor samples with muscle invasive bladder carcinoma (n = 400)	Poor prognosis	Positively correlates with EMT-associated genes	[56]
Staphylococcaceae	Enriched	Prostate	prostatic tumor, peritumor and nontumor tissues	Oncogenesis		[57]
Pseudomonas, Escherichia, Acinetobacter, Propionibacterium spp.	Enriched		frozen radical prostate samples from tumor and adjacent benign tissue	Oncogenesis		[58]
	Enriched		Propionibacterium acnes spp	Prostate tissue inflammation		[59]
Proteobacteria	Enriched		Prostatic tumor tissues	Oncogenesis		[60]
Enterobacteriaceae Pseudomonadaceae	Enriched	Pancreatic	Pancreatic ductal adenocarcinoma tissues and normal human pancreas	Chemotherapy resistance	Metabolize chemotherapy drugs	[32]
Proteobacteria Bacteroidetes Firmicutes	Enriched		Pancreatic cancer and normal tissues	Tumor progression	Modulating M1 macrophage/Th1 differentiation, that affect CD8 + T cell function	[61]
Pseudoxanthomonas Streptomyces Saccharopolyspora Bacillus clausii	Enriched		pancreatic adenocarcinoma (PDAC) patients with short-term survival (STS, < 5 years) and long-term survival (LTS, > 5 years)	Prognosis	Elevated infiltration and activation of CD8 T cells	[62]
F. nucleatum	Enriched	Mouth	Oral squamous cell carcinoma and normal oral tissues	Predictor	Promotes EMT transition	[63]
Abundance of Firmicutes (especially Streptococcus) and Actinobacteria (especially Rothia)	Bacterial dysbiosis		Oral cancers and anatomically matched contralateral normal tissue		Promote oncogenesis and progression	[64]
Fusobacterium/Prevotella	Enriched		Oral squamous cell carcinoma tissues and adjacent non-tumor mucosa 5 cm distant	Oncogenesis	NT	[65]
Peptostreptococcus	Enriched		Tumor samples from patients with OSCC	Better prognosis	NT	[66]
F. nucleatum	Enriched	Colon	Colorectal cancer and paired normal tissues	Oncogenesis and progression	Activates β-catenin signaling; Lower density of CD3⁺ T cells; Recruits immuno- suppressive cells; Inactivation of NK and T cells	[67,68,69,70,71,72,73]
Escherichia coli and Bacteroides fragilis	Enriched		Familial adenomatous polyposis samples and healthy controls	Promotes cancer initiation	that secrete oncotoxins	[34]
Fusobacterium	Enriched		Paired primary colorectal and metastatic tumors	Cancer metastasis	NT	[70]
Helicobacter spp	Enriched	Bile duct	Bile duct cancer tissues	Oncogenesis	NT	[74]
Fusobacterium nucleatum, Escherichia coli, and Enterobacter sp.	Enriched	Gallbladder	Bile samples from patients with gallbladder cancer and cholelithiasis	Oncogenesis	NT	[75]
Decreased Nesterenkonia, and increased Methylophilaceae, Fusobacterium, Prevotella, Actinomyces, Novosphingobium, and H. pylori	Bacteria dysbiosis	Extrahepatic cholangiocarcinoma	Tissues from extrahepatic cholangiocarcinoma (ECCA) and benign biliary pathology (BBP) cohorts	Oncogenesis	NT	[76]
Helicobacter bilis	Enriched	Extrahepatic cholangiocarcinoma	Tissues from extrahepatic cholangiocarcinoma (ECCA) and benign biliary pathology (BBP) cohorts	Oncogenesis	NT	[77]
Bifidobacteriaceae Enterobacteriaceae Enterococcaceae	Enriched	Cholangiocarcinoma	primary CCA tumors and matched normal tissues	Oncogenesis	NT	[78]
Helicobacter species	Enriched	Hepatocellular carcinoma	Liver samples from patients with hepatocellular carcinoma, non-cirrhotic chronic hepatitis C, and healthy controls	Oncogenesis	NT	[79]
Sneathia and Lactobacillus	Dysbiosis	Cervix				[80]
Fusobacterium spp	Enriched		Samples from patients with squamous intraepithelial lesions (SIL) and cervical cancer	Oncogenesis	NT	[81]
L. gasseri	Enriched			Oncogenesis	NT	[82]
Atopobium, Porphyromonas, Dialister, Peptoniphilus, Ruminococcus, Anaerotruncus, Anaerostipes, Treponema, Bacteroides and Arthrospira	Enriched	Endometrium	Uterine samples from cancer and benign disease	Oncogenesis	Modulating the vaginal pH	[83]
Brucella, Mycoplasma, Chlamydia spp.	Enriched	Ovary	Ovarian tumor	Oncogenesis		[84]
Proteobacteria	Enriched		Ovarian cancer tissues and normal distal fallopian tube tissues	Cancer initiation and progression	Modulating immune response	[85]
Actinomyces and Parvimonas	Dysbiosis	Head and neck squamous cell carcinomas (OSCC)	Paired normal and tumor resected OSCC specimens	Tumor stage	NT	[86]

Back to article page

ISSN: 2050-7771

Contact us

General enquiries: journalsubmissions@springernature.com