Table 2 Exosomal circRNA implicate in hematological malignancies
From: The emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies
Diseases | Exosomal circRNA | Levels | miRNAs, RBPs, and pathways targeted | Impact on Hematologic disease | References |
|---|---|---|---|---|---|
AML | circ_0004136 | up | miR-570-3p/TSPAN3 | Increase AML cell viability, cell cycle progression, migration and invasion and decreased apoptosis | [94] |
AML | circ_0009910 | up | miR‐5195‐3p/GRB10 | Increase proliferation, apoptosis and cell cycle progression of AML cells | [95] |
CLL | mc-COX2 | up | - | Dampen mitochondrial functions and regulates CLL cell growth | [96] |
MM | circMYC | up | - | Associate with the recurrence and Bortezomib resistance | [97] |
MM | chr2:2,744,228–2,744,407 + | up | hsa-miR-6829-3p/GRIN2B | Neuronal cell death and MM-related PN | [98] |
MM | circ-G042080 | up | hsa-miR-4268/TLR4 | Associate with MM-related myocardial damage and increase autophagy level in cardiomyocytes | [99] |