Fig. 1From: Nanobody-based CAR-T cells for cancer immunotherapyThe structural characteristics of CAR generations developed to date. These five generations of CARs only have differences in their intracellular domains. AD, activation domain; CS, costimulatory domain; scFv, single-chain fragment variable; TM, transmembrane domain; VH, heavy chain variable domain; VHH, single variable domain on a heavy chain; VL, light chain variable domainBack to article page