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Fig. 1 | Biomarker Research

Fig. 1

From: Nanobody-based CAR-T cells for cancer immunotherapy

Fig. 1

The structural characteristics of CAR generations developed to date. These five generations of CARs only have differences in their intracellular domains. AD, activation domain; CS, costimulatory domain; scFv, single-chain fragment variable; TM, transmembrane domain; VH, heavy chain variable domain; VHH, single variable domain on a heavy chain; VL, light chain variable domain

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