Fig. 2

The regulatory and antitumor functions of DNTs. The antitumor functions of DNTs depend on expression of FasL, NKG2D, DNAM-1, TRAIL and NKp30. Moreover, secretion of IFN-γ, TNF-α, granzyme B and perforin take an important place. In addition, DNTs can mediate many types of immunocyte and exert immunoregulatory functions. DNTs downregulate expression of CD80/CD86 in dendritic cell and impact their interaction with other cells. DNTs can express MHC-peptide complex which expressed in dendritic cell by trogocytosis way, then interact with T cell and kill them through Fas/Fas L manner. Granzyme B and perforin secretion by DNTs induce death of T cell and B cell. Alternatively, DNTs kill M1 macrophage by down-regulating TNF-α and IFN-γ secretion of M1. FasL, Fas ligand; TNF-α, tumor necrosis factor α; NKG2D, natural killer group 2-member D; TRAIL: tumour necrosis factor-related apoptosis-inducing ligand