From: Clinical translation of patient-derived tumour organoids- bottlenecks and strategies
System | Cancer Type | Success Rate of PDTOs | Reference |
---|---|---|---|
Digestive | Pancreatic Cancer | 62% (52/83) | [34] |
75% (103/138) | [35] | ||
85% (17/20) | [36] | ||
 | [20] | ||
Colorectal Cancer | 100% | [37] | |
~ 90% (22/27) | [38] | ||
Hepatocellular Carcinoma | 26% (10/38) | [39] | |
100% (13/17) | [40] | ||
Gastric Carcinoma | 50% | [41] | |
71% (10/14) | [42] | ||
Metastatic Gastrointestinal Carcinoma | 70% (> 100) | [43] | |
76% (13/17) | [44] | ||
Esophageal Carcinoma | 31% (10/32) | [45] | |
Appendiceal Carcinoma | 75% (9/12) | [46] | |
Respiratory | Lung Carcinoma | 88% (n = 16) | [47] |
Non-Small Cell Lung Cancer | 71.43% (10/14) | [48] | |
(Primary & Metastatic) | 100% (3/3) | [49] | |
28% (n = 18) | [47] | ||
Mesothelioma | 100% (2/2) | [50] | |
Urinary | Prostate Cancer (Primary & Metastatic) | 16% (4/25) | [51] |
18% (6/32) | [52] | ||
Bladder Carcinoma | 70% (12/17) | [53] | |
Renal Cell Carcinoma | 74% (25/35) | [54] | |
Reproductive | Breast carcinoma | ~ 80% (> 155) | [30] |
Endometrial Carcinoma | 100% (15/15) | [29] | |
Ovarian Cancer | 65% (n = 32) | [55] | |
Nervous | Glioblastoma | 91.4% overall | [56] |
66.7% (IDH1 mutant) | Â | ||
75% (recurrent) | Â |