Table 1 Chromosomal aberrations and mutational landscape occurrence in ETP-ALL and non ETP-ALL. Marks indicate the disease subtype in which the alteration is more frequent
From: Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick
ETP-ALL | Non ETP-ALL | ||
|---|---|---|---|
Chromosomal aberrations | 13q deletion | ⎫ | |
14q32 rearrangements | ⎫ | ||
LMO1/2, TLX1, TLX3, STIL rearrangements | ⎫ | ||
KMT2A rearrangements | ⎫ | ||
TCR rearrangements | ⎫ | ||
CDKN2A/B deletion | ⎫ | ||
Mutational landscape | RUNX1, IKZF1, ETV6, GATA3, EP300 (hematopoietic development) | ⎫ | |
BRAF, FLT3, IGFR1, JAK1, JAK3, KRAS, NRAS, IL7r (RAS and cytokine receptor/JAK-STAT signalling) | ⎫ | ||
EED, SUZ12, EZH2 (histone-modifying genes) | ⎫ | ||
DNM2, ECT2, RELN (lymphoid development) | ⎫ | ||
NOTCH1 and FBXW7 | ⎫ | ||
FLT3 | ⎫ | ||
DNMT3A and FAT3 | ⎫ | ||
NPM1 | ⎫ | ||