Fig. 1
From: Next frontier in tumor immunotherapy: macrophage-mediated immune evasion
The mechanisms of macrophages participating in tumor antigen recognition disorder. Certain tumor cells highly express self-labels like CD47, β2M and CD24, which can phosphorylate ITIMs through CD47/SIRPα, β2M/LILRB and CD24/Siglec-10 signal axis respectively, activate downstream pathways, release anti phagocytic signal and negatively regulate phagocytic function of macrophages