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Table 5 Comparisons of baseline/post/change between good vs poor response in Cohort B

From: Small molecule tyrosine kinase inhibitors modulated blood immune cell counts in patients with oncogene-driven NSCLC

Response Good Response Poor Response Difference (Good - Poor)
Timepoints Baseline Post-treatment Change (Post - Pre) Baseline Post-treatment Change (Post - Pre) Baseline Post-treatment Change
Blood biomarker Mean (±SD) Mean (±SD) Mean (±SD) Mean (±SD) Mean (±SD) Mean (±SD) Mean (±SE) P-value$ Mean (±SE) P-value$ Mean (±SE) P-value$
WBC (×103 cells/μL) 7.1 (±2.5) 6.9 (±1.9) −0.3 (±2.1) 8.0 (±2.4) 7.4 (±3.0) −0.6 (±3.3) −0.8 (±0.8) 0.329 −0.5 (±0.8) 0.756 0.3 (±0.9) 0.682
Hemoglobulin (gram/dL) 13.0 (±1.4) 12.6 (±1.3) −0.4 (±1.5) 12.4 (±2.4) 11.7 (±1.6) −0.7 (±2.8) 0.6 (±0.6) 0.388 0.9 (±0.5) 0.138 0.3 (±0.8) 0.434
Platelet count (×103 cells/μL) 278.2 (±98.3) 278.0 (±118.1) −0.2 (±68.1) 300.0 (±152.1) 260.1 (±160.2) −39.9 (±105.8) −21.8 (±43.0) 0.961 17.9 (±47.4) 0.379 39.7 (±29.9) 0.321
ANC (×103 cells/μL) 5.2 (±2.3) 4.5 (±1.7) −0.7 (±2.1) 6.0 (±1.9) 5.4 (±2.3) −0.6 (±2.7) −0.7 (±0.7) 0.249 −0.9 (±0.7) 0.230 −0.1 (±0.8) 0.844
ALCs (×103 cells/μL) 1.1 (±0.6) 1.3 (±0.8) 0.3 (±0.4) 1.1 (±0.5) 0.8 (±0.3) −0.3 (±0.3) −0.1 (±0.2) 0.523 0.5 (±0.2) 0.032 0.6 (±0.1) < 0.001
CD3 + CD4 + % 48.8 (±12.6) 47.2 (±13.1) −1.6 (±8.3) 41.6 (±11.9) 39.1 (±14.0) −2.5 (±5.6) 7.2 (±4.2) 0.083 8.1 (±4.6) 0.111 0.9 (±2.4) 0.211
CD3 + CD8 + % 23.3 (±10.4) 25.4 (±12.6) 2.1 (±7.3) 31.0 (±13.5) 32.0 (±15.7) −1.0 (±8.0) −7.7 (±4.1) 0.098 −6.6 (±4.8) 0.200 1.1 (±2.6) 0.534
CD3 + % 72.0 (±7.8) 72.6 (±9.3) 0.6 (±8.1) 72.8 (±12.6) 71.5 (±13.4) −1.3 (±5.3) −0.8 (±3.5) 0.806 1.1 (±3.9) 0.961 1.8 (±2.3) 0.150
CD3 + CD4+ count (cells/μL) 502.9 (±284.4) 593.4 (±297.3) 90.6 (±136.1) 481.1 (±300.4) 310.8 (±204.2) −170.2 (±209.4) 21.8 (±98.8) 0.831 282.6 (±86.7) 0.008 260.8 (±59.3) < 0.001
CD3 + CD8+ count (cells/μL) 279.5 (±322.5) 400.1 (±476.1) 120.6 (±191.6) 333.1 (±178.1) 215.2 (±106.2) − 117.9 (±153.2) −53.6 (±88.8) 0.060 184.9 (±118.2) 0.321 238.5 (±58.9) < 0.001
CD4/CD8 ratio 2.6 (±1.3) 2.4 (±1.3) −0.2 (±0.9) 1.6 (±1.2) 1.7 (±1.2) 0.0 (±0.7) 1.0 (±0.4) 0.033 0.7 (±0.4) 0.089 −0.2 (±0.3) 0.922
CD4 plus CD8 count (cells/μL) 782.4 (±482.8) 993.6 (±627.4) 211.2 (±268.1) 814.2 (±384.3) 526.1 (±251.2) −288.1 (±329.2) −31.8 (±148.1) 0.567 467.5 (±163.4) 0.011 499.3 (±101.2) < 0.001
dNLR 3.1 (±1.7) 2.4 (±1.8) −0.7 (±1.6) 3.4 (±1.3) 3.9 (±2.7) 0.6 (±2.5) −0.2 (±0.5) 0.590 −1.5 (±0.8) 0.030 −1.3 (±0.7) 0.160
  1. $P-values from Wilcoxon rank sum tests. Bold for statistical significance
  2. Abbreviation: SD Standard Deviation, SE Standard Error