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Table 2 Pivotal driver mutations of Wnt components occur in cancers

From: The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy

Mutated driver gene Types of cancer References
CTNNB1 sinonasal teratocarcinosarcomas [30]
hepatocellular carcinoma [31]
pancreatic cancer [32]
colon cancer [33]
lung cancer [34]
endometrioid endometrial carcinoma [35]
mucosal melanomas [36]
gastric cancer [42]
APC colorectal cancer [37,38,39,40,41]
gastric cancer [42]
RNF43 pancreatic ductal adenocarcinoma [43]
gastric cancer [45]
intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs) [46]
colorectal and endometrial cancers [38, 44]
IPMNs of pancreas [47]
colitis-associated cancer [49]
gastric cancer [50]
mucinous tumors of the ovary [51]
ZNRF3 adrenocortical carcinoma [54]
AXIN2 colorectal cancer [55, 56]
AXIN1 hepatocellular carcinomas [57]