Table 2 Pivotal driver mutations of Wnt components occur in cancers

CTNNB1

sinonasal teratocarcinosarcomas

[30]

hepatocellular carcinoma

[31]

pancreatic cancer

[32]

colon cancer

[33]

lung cancer

[34]

endometrioid endometrial carcinoma

[35]

mucosal melanomas

[36]

gastric cancer

[42]

APC

colorectal cancer

[37,38,39,40,41]

gastric cancer

[42]

RNF43

pancreatic ductal adenocarcinoma

[43]

gastric cancer

[45]

intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs)

[46]

colorectal and endometrial cancers

[38, 44]

IPMNs of pancreas

[47]

colitis-associated cancer

[49]

gastric cancer

[50]

mucinous tumors of the ovary

[51]

ZNRF3

adrenocortical carcinoma

[54]

AXIN2

colorectal cancer

[55, 56]

AXIN1

hepatocellular carcinomas

[57]