Fig. 9
From: Imaging biomarkers for evaluating tumor response: RECIST and beyond
Low apparent diffusion coefficient (ADC) value on diffusion-weighted imaging (DWI) can predict worse therapeutic response in brain glioblastoma. A Pretreatment CE axial T1-weighted imaging (T1WI) shows a 40-mm-sized enhancing glioblastoma (arrow) with the cystic component in the left temporal lobe. B The DWI shows hyperintensity in the solid part of the tumor (arrow), indicating a diffusion restriction phenomenon. C The measured ADC value (b = 1000 s/mm2) on ROI is 0.72 × 10− 3 mm2/sec. (D) Rapid tumor recurrence (tumor diameter of 54 mm) (curved arrow) was observed 3 months after surgical resection. E Pretreatment CE axial T1WI shows another 65-mm-sized enhancing glioblastoma (open arrow) with a cystic component in the left frontal lobe. F DWI shows isointensity (no diffusion restriction) in the solid part of the tumor (open arrow). G The measured ADC value on ROI is 1.42 × 10− 3 mm2/sec. (H) No tumor recurrence was observed 72 months after surgical resection