Fig. 8

MRI-dynamic contrast-enhanced (DCE) kinetic curve can be used to predict chemotherapy response. A - C The upper panel shows a woman with breast cancer in the right breast. The tumor responded very well to chemotherapy. After one cycle of Adriamycin and Cyclophosphamide (AC), and 4 cycles of AC or taxane, the tumor size was remarkably reduced (white arrows). D Note the change of the DCE kinetic curves, acquired from the pretreatment MRI (blue) and after 1 cycle of AC (red), from washout pattern to more flattened pattern, indicating the malignant cells were being eliminated. E - G The lower panel is a woman of non-responder. The breast cancer in the left breast was not reduced in size following chemotherapy (red arrows). H Note the DCE kinetic curve acquired from MRI after 1 cycle of AC (red), became more apparently a washout pattern compared with the pre-treatment curve (blue)