Table 1 E-Cadherin immunostaining in human tumors
From: E-Cadherin expression in human tumors: a tissue microarray study on 10,851 tumors
Tumor type | n on TMA | E-Cadherin expression | ||||||
|---|---|---|---|---|---|---|---|---|
analyzable (n) | negative (%) | weak (%) | moderate (%) | strong (%) | positive (%) | |||
Tumors of the skin | Pilomatrixoma | 35 | 33 | 72.7 | 3.0 | 15.2 | 9.1 | 27.3 |
Basal cell carcinoma | 48 | 33 | 0.0 | 0.0 | 3.0 | 97.0 | 100.0 | |
Benign nevus | 29 | 15 | 6.7 | 53.3 | 33.3 | 6.7 | 93.3 | |
Squamous cell carcinoma of the skin | 50 | 29 | 0.0 | 0.0 | 6.9 | 93.1 | 100.0 | |
Malignant melanoma | 48 | 39 | 23.1 | 10.3 | 5.1 | 61.5 | 76.9 | |
Merkel cell carcinoma | 46 | 41 | 75.6 | 19.5 | 2.4 | 2.4 | 24.4 | |
Tumors of the head and neck | Squamous cell carcinoma of the larynx | 50 | 39 | 2.6 | 5.1 | 0.0 | 92.3 | 97.4 |
Squamous cell carcinoma of the pharynx | 50 | 43 | 2.3 | 0.0 | 9.3 | 88.4 | 97.7 | |
Oral squamous cell carcinoma (floor of the mouth) | 50 | 36 | 0.0 | 2.8 | 5.6 | 91.7 | 100.0 | |
Pleomorphic adenoma of the parotid gland | 49 | 45 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Warthin tumor of the parotid gland | 15 | 14 | 0.0 | 0.0 | 7.1 | 92.9 | 100.0 | |
Tumors of the lung, pleura and thymus | Basal cell adenoma of the salivary gland | 250 | 123 | 0.0 | 5.7 | 3.3 | 91.1 | 100.0 |
Adenocarcinoma of the lung | 127 | 54 | 1.9 | 0.0 | 9.3 | 88.9 | 98.1 | |
Squamous cell carcinoma of the lung | 20 | 15 | 6.7 | 6.7 | 0.0 | 86.7 | 93.3 | |
Small cell carcinoma of the lung | 76 | 56 | 55.4 | 3.6 | 16.1 | 25.0 | 44.6 | |
Mesothelioma, epitheloid | 39 | 22 | 4.5 | 13.6 | 36.4 | 45.5 | 95.5 | |
Thymoma | 29 | 27 | 11.1 | 3.7 | 14.8 | 70.4 | 88.9 | |
Tumors of the female genital tract | Squamous cell carcinoma of the vagina | 48 | 18 | 0.0 | 11.1 | 5.6 | 83.3 | 100.0 |
Squamous cell carcinoma of the vulva | 50 | 26 | 0.0 | 7.7 | 11.5 | 80.8 | 100.0 | |
Squamous cell carcinoma of the cervix | 50 | 29 | 3.4 | 0.0 | 3.4 | 93.1 | 96.6 | |
Adenocarcinoma of the cervix uteri | 50 | 37 | 2.7 | 5.4 | 5.4 | 86.5 | 97.3 | |
Endometrioid endometrial carcinoma | 236 | 200 | 1.5 | 12.5 | 15.5 | 70.5 | 98.5 | |
Endometrial serous carcinoma | 82 | 49 | 12.2 | 10.2 | 16.3 | 61.2 | 87.8 | |
Carcinosarcoma of the uterus | 48 | 32 | 25.0 | 25.0 | 15.6 | 34.4 | 75.0 | |
Endometrial clear cell carcinoma | 8 | 7 | 0.0 | 42.9 | 28.6 | 28.6 | 100.0 | |
Endometrial carcinoma, high grade, G3 | 13 | 11 | 27.3 | 36.4 | 0.0 | 36.4 | 72.7 | |
Endometrial stromal sarcoma | 12 | 11 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Endometrioid carcinoma of the ovary | 115 | 84 | 1.2 | 3.6 | 6.0 | 89.3 | 98.8 | |
Serous carcinoma of the ovary | 567 | 480 | 4.0 | 11.5 | 21.3 | 63.3 | 96.0 | |
Mucinous carcinoma of the ovary | 97 | 69 | 1.4 | 0.0 | 4.3 | 94.2 | 98.6 | |
Clear cell carcinoma of the ovary | 54 | 48 | 4.2 | 6.3 | 10.4 | 79.2 | 95.8 | |
Carcinosarcoma of the ovary | 47 | 42 | 26.2 | 14.3 | 11.9 | 47.6 | 73.8 | |
Brenner tumor | 9 | 6 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Tumors of the breast | Invasive breast carcinoma of no special type | 1391 | 820 | 1.1 | 2.4 | 3.7 | 92.8 | 98.9 |
Lobular carcinoma of the breast | 294 | 158 | 71.5 | 8.9 | 6.3 | 13.3 | 28.5 | |
Medullary carcinoma of the breast | 26 | 8 | 0.0 | 0.0 | 25.0 | 75.0 | 100.0 | |
Tubular carcinoma of the breast | 27 | 6 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Mucinous carcinoma of the breast | 58 | 16 | 0.0 | 6.3 | 6.3 | 87.5 | 100.0 | |
Phyllodes tumor of the breast | 50 | 29 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Tumors of the digestive system | Adenomatous polyp, low-grade dysplasia | 50 | 39 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 |
Adenomatous polyp, high-grade dysplasia | 50 | 37 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Adenocarcinoma of the colon | 1882 | 1644 | 0.5 | 5.5 | 9.7 | 84.3 | 99.5 | |
Adenocarcinoma of the small intestine | 10 | 5 | 0.0 | 20.0 | 0.0 | 80.0 | 100.0 | |
Gastric adenocarcinoma, diffuse type | 176 | 147 | 10.2 | 3.4 | 2.0 | 84.4 | 89.8 | |
Gastric adenocarcinoma, intestinal type | 174 | 144 | 0.7 | 2.1 | 3.5 | 93.8 | 99.3 | |
Gastric adenocarcinoma, mixed type | 62 | 52 | 7.7 | 5.8 | 1.9 | 84.6 | 92.3 | |
Adenocarcinoma of the esophagus | 133 | 62 | 0.0 | 1.6 | 1.6 | 96.8 | 100.0 | |
Squamous cell carcinoma of the esophagus | 124 | 55 | 0.0 | 3.6 | 0.0 | 96.4 | 100.0 | |
Squamous cell carcinoma of the anal canal | 50 | 30 | 0.0 | 0.0 | 3.3 | 96.7 | 100.0 | |
Cholangiocarcinoma | 114 | 93 | 0.0 | 3.2 | 7.5 | 89.2 | 100.0 | |
Hepatocellular carcinoma | 50 | 45 | 2.2 | 8.9 | 11.1 | 77.8 | 97.8 | |
Ductal adenocarcinoma of the pancreas | 612 | 437 | 0.9 | 2.3 | 9.6 | 87.2 | 99.1 | |
Pancreatic/Ampullary adenocarcinoma | 89 | 61 | 3.3 | 4.9 | 3.3 | 88.5 | 96.7 | |
Acinar cell carcinoma of the pancreas | 13 | 12 | 0.0 | 0.0 | 8.3 | 91.7 | 100.0 | |
Gastrointestinal stromal tumor (GIST) | 50 | 40 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Tumors of the urinary system | Non-invasive papillary urothelial carcinoma, pTa G2 low grade | 177 | 95 | 15.8 | 6.3 | 11.6 | 66.3 | 84.2 |
Non-invasive papillary urothelial carcinoma, pTa G2 high grade | 141 | 91 | 3.3 | 5.5 | 6.6 | 84.6 | 96.7 | |
Non-invasive papillary urothelial carcinoma, pTa G3 | 187 | 125 | 3.2 | 7.2 | 8.8 | 80.8 | 96.8 | |
Urothelial carcinoma, pT2–4 G3 | 940 | 755 | 4.4 | 6.4 | 8.5 | 80.8 | 95.6 | |
Small cell neuroendocrine carcinoma of the bladder | 18 | 18 | 44.4 | 5.6 | 11.1 | 38.9 | 55.6 | |
Sarcomatoid urothelial carcinoma | 25 | 15 | 60.0 | 0.0 | 6.7 | 33.3 | 40.0 | |
Clear cell renal cell carcinoma | 858 | 614 | 51.3 | 25.7 | 13.8 | 9.1 | 48.7 | |
Papillary renal cell carcinoma | 255 | 180 | 58.3 | 26.1 | 6.1 | 9.4 | 41.7 | |
Chromophobe renal cell carcinoma | 131 | 103 | 1.0 | 2.9 | 3.9 | 92.2 | 99.0 | |
Oncocytoma | 177 | 127 | 2.4 | 3.1 | 12.6 | 81.9 | 97.6 | |
Clear cell (tubulo) papillary renal cell carcinoma | 21 | 14 | 42.9 | 14.3 | 14.3 | 28.6 | 57.1 | |
Tumors of the male genital organs | Adenocarcinoma of the prostate, Gleason 3 + 3 | 83 | 73 | 0.0 | 1.4 | 1.4 | 97.3 | 100.0 |
Adenocarcinoma of the prostate, Gleason 4 + 4 | 80 | 70 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Adenocarcinoma of the prostate, Gleason 5 + 5 | 85 | 76 | 2.6 | 0.0 | 0.0 | 97.4 | 97.4 | |
Adenocarcinoma of the prostate (recurrence) | 330 | 217 | 8.3 | 3.2 | 8.3 | 80.2 | 91.7 | |
Small cell neuroendocrine carcinoma of the prostate | 17 | 13 | 15.4 | 0.0 | 0.0 | 84.6 | 84.6 | |
Seminoma | 624 | 522 | 42.3 | 27.2 | 14.6 | 15.9 | 57.7 | |
Embryonal carcinoma of the testis | 50 | 44 | 0.0 | 6.8 | 18.2 | 75.0 | 100.0 | |
Yolk sack tumor | 50 | 36 | 8.3 | 19.4 | 5.6 | 66.7 | 91.7 | |
Teratoma | 50 | 19 | 10.5 | 5.3 | 0.0 | 84.2 | 89.5 | |
Tumors of endocrine organs | Adenoma of the thyroid gland | 114 | 104 | 0.0 | 2.9 | 9.6 | 87.5 | 100.0 |
Papillary thyroid carcinoma | 392 | 354 | 0.0 | 3.7 | 7.6 | 88.7 | 100.0 | |
Follicular thyroid carcinoma | 158 | 147 | 0.0 | 6.8 | 10.9 | 82.3 | 100.0 | |
Medullary thyroid carcinoma | 107 | 84 | 1.2 | 16.7 | 39.3 | 42.9 | 98.8 | |
Anaplastic thyroid carcinoma | 45 | 35 | 68.6 | 17.1 | 2.9 | 11.4 | 31.4 | |
Adrenal cortical adenoma | 50 | 43 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Adrenal cortical carcinoma | 26 | 20 | 90.0 | 0.0 | 0.0 | 10.0 | 10.0 | |
Phaeochromocytoma | 50 | 42 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Appendix, neuroendocrine tumor (NET) | 22 | 13 | 7.7 | 0.0 | 7.7 | 84.6 | 92.3 | |
Colorectal, neuroendocrine tumor (NET) | 10 | 10 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Ileum, neuroendocrine tumor (NET) | 49 | 43 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Lung, neuroendocrine tumor (NET) | 19 | 14 | 0.0 | 14.3 | 7.1 | 78.6 | 100.0 | |
Pancreas, neuroendocrine tumor (NET) | 102 | 75 | 2.7 | 5.3 | 4.0 | 88.0 | 97.3 | |
GIT & pancreas neuroendocrine carcinoma (NEC) | 28 | 11 | 27.3 | 9.1 | 9.1 | 54.5 | 72.7 | |
Tumors of haemotopoetic and lymphoid tissues | Hodgkin Lymphoma | 45 | 38 | 73.7 | 0.0 | 5.3 | 21.1 | 26.3 |
Non-Hodgkin Lymphoma | 48 | 39 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Tumors of soft tissue and bone | Tenosynovial giant cell tumor | 45 | 37 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Granular cell tumor | 53 | 34 | 97.1 | 2.9 | 0.0 | 0.0 | 2.9 | |
Leiomyoma | 50 | 45 | 97.8 | 0.0 | 0.0 | 2.2 | 2.2 | |
Angiomyolipoma | 91 | 64 | 37.5 | 35.9 | 9.4 | 17.2 | 62.5 | |
Angiosarcoma | 73 | 51 | 94.1 | 0.0 | 0.0 | 5.9 | 5.9 | |
Dermatofibrosarcoma protuberans | 21 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Ganglioneuroma | 14 | 9 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Kaposi sarcoma | 8 | 5 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Leiomyosarcoma | 87 | 72 | 76.4 | 4.2 | 9.7 | 9.7 | 23.6 | |
Liposarcoma | 132 | 89 | 98.9 | 1.1 | 0.0 | 0.0 | 1.1 | |
Malignant peripheral nerve sheath tumor (MPNST) | 13 | 11 | 90.9 | 9.1 | 0.0 | 0.0 | 9.1 | |
Myofibrosarcoma | 26 | 23 | 95.7 | 4.3 | 0.0 | 0.0 | 4.3 | |
Neurofibroma | 117 | 99 | 99.0 | 1.0 | 0.0 | 0.0 | 1.0 | |
Sarcoma, not otherwise specified (NOS) | 75 | 58 | 94.8 | 5.2 | 0.0 | 0.0 | 5.2 | |
Paraganglioma | 41 | 38 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Primitive neuroectodermal tumor (PNET) | 23 | 13 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Rhabdomyosarcoma | 7 | 6 | 66.7 | 33.3 | 0.0 | 0.0 | 33.3 | |
Schwannoma | 121 | 100 | 70.0 | 24.0 | 4.0 | 2.0 | 30.0 | |
Synovial sarcoma | 12 | 9 | 66.7 | 33.3 | 0.0 | 0.0 | 33.3 | |
Osteosarcoma | 43 | 27 | 96.3 | 3.7 | 0.0 | 0.0 | 3.7 | |
Chondrosarcoma | 39 | 17 | 88.2 | 5.9 | 5.9 | 0.0 | 11.8 | |