Fig. 3

Progenitor (T-bet^hiEomes^dim/−PD1^mid) and terminally (T-bet^dim/−Eomes^hiPD1^hi) exhausted CD8⁺ T cells in progressing and non-progressing CLL patients. a Percentages of T-bet^hiEomes^dim/− out of PD1^midCD8⁺ T cells and b T-bet^dim/−Eomes^hi out of PD1^hiCD8⁺ T cells in progressing (left, n = 12) and non-progressing patients (middle, n = 9) at diagnosis and progression or non-progression. Fold change between time points of both subsets comparing progressing and non-progressing patients (right). c Representative viSNE plots of PD1, T-bet and Eomes expression in CD4⁺ and CD8⁺ T cells at the two time points from one representative patient from each group. Graphs show mean ± SEM or paired values. (*P < 0.05; **P < 0.01; ***P < 0.001; Wilcoxon matched paired test or Mann-Whitney test)