Fig. 5

Gene enrichment analysis of the 9 miRNA-biological signature. Enrichment analysis of 7 T/N-downregulated (a), and 2 T/N-upregulated (b) miRNA gene targets. Analysis was performed by GSEA 4.1.0 software (BROAD Inst.) and run in pre-ranked mode. Predicted targets were ranked based on the correlation coefficients obtained from miRNA\mRNA TCGA RNA-sequencing data. Results showed normalized scores for negative enrichment (a) and positive enrichment (b). Color bar indicates the false discovery rate and the circle size represents the percentage of the genes in the core enrichment pathway. Abbreviations: T/N = tumor versus normal; NES = normalized enrichment score; path. = pathway; sign. = signaling