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Table 1 Immune cell types and functions in AML BM microenvironment

From: Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment

Cluster Subset Feature genes Anti-tumor or immunosuppressive /dysfunctional
Mast cell High: KIT, GATA2, LMO4, CPA3, TPSAB1, TPSB2 Anti-tumor
DC pDC High: CD36, FLT3, LY86, PTPRCAP, GLIPR2, IL3RA, SEMA4D, JCHAIN, TNFSF4, TNFSF13, LTB, HGF, CCL28; Low: LYZ Anti-tumor
CD206+ DC High: MRC1, FCER1A, IFI30, IL18, FCGR2A, FCGR2B, FCGR2C, CD4, TNFSF12, TNFSF8 Immunosuppressive
CLEC7A+ DC High: CLEC7A, ITGAE Undefined
CD1C+ DC High: AREG, S100A8, S100A9, CD86, CD1C, CLEC9A, ANPEP, FBXO27 Undefined
CX3CR1+ DC High: CX3CR1, CD8A, CD274, PDCD1LG2, TNFSF14, BTLA, CD70, TNFSF10, CCL5 Immunosuppressive
Mono/Mac MS4A6Ahigh subset High: MS4A6A, CD86, CSF1R, TGFB1, CCL22 Immunosuppressive
CD163high subset High: CD163, CXCR4, IL4R, TGFB1, CCL18 Immunosuppressive
MKI67+ subset High: MKI67, VEGFA Undefined
MARCOhigh subset High: IL1B, MARCO, CD4, CD68, CD86, CD14, CD163, IL4R, CSF1R, CX3CR1, TGFB1 Immunosuppressive
FCGR3A+ subset High: CX3CR1, FCGR3A, CSF1R Anti-tumor
MRC1+ subset High: MRC1, CSF1R, TGFB1 Immunosuppressive
CD14highITGAMhigh subset High: CCR2, ITGAM, CD14 Undefined
CXCL8high subset High: HIF1A, CXCL8 Undefined
IL10highTGFB1high subset High: IL10, TGFB1 Immunosuppressive
T CD4+ naïve T cell High: CD4, CCR7, LEF1, TCF7, SELL Dysfunctional
CD69highGZMACD4+ T cell High: CD4, CD69; Low: GZMA Anti-tumor
CD69highGZMA+CD4+ T cell High: CD4, CD69, GZMA Anti-tumor
CD4+ cytotoxic T High: CD4, GZMA, GZMB, GZMH, GNLY, NKG7 Anti-tumor
TH17-like cell High: CD4, RORC, KLRB1 Dysfunctional
Treg High: CD4, IL2RA, FOXP3; Low: CD127 Immunosuppressive
Proliferating T cell High: CD4, MKI67, PCNA, HAVCR2, LAG3, PRDM1, TIGIT, CTLA4, TOX Dysfunctional
IFN-CD4+ T cell High: CD4, IFIT3, ISG15, ISG20, MX1, IFNAR1, LAG3, PRDM1, TIGIT Dysfunctional
GZMAlowGNLY+CD8+ T cell High: CD8, GNLY; Low: GZMA Anti-tumor
TIGIT+CD8+ T cell High: CD8, LAG3, TIGIT, GZMH, GZMA, GNLY, PRF1, GZMB Dysfunctional
Naïve CD8+ T High: CD8, TCF7, SELL, LEF1, CCR7 Undefined
GZMAlowGNLYlowCD8+ T cell High: CD8, CD69, RUNX3, IL7R; Low: KLRG1, ITGAE, B3GAT1, GZMA, GZMB, GZMH, GZMK, GNLY, PRF1, NKG7 Anti-tumor
GZMA+GNLYlowCD8+ T High: CD8, GZMA, TIGIT, PDCD1, CTLA4 Dysfunctional
NK NK cell High: TYROBP, KLRF1, FCGR3A, NCAM1, CD160, GZMA, GNLY, PRF1, GZMB, TIGIT, HAVCR2; Low: CD3D, CD3E, CD8A, CD8B Dysfunctional