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Fig. 1 | Biomarker Research

Fig. 1

From: Novel immunomodulatory drugs and neo-substrates

Fig. 1

Chemical structure and mechanism of action of IMiDs. a Chemical structure of thalidomide, lenalidomide, pomalidomide, CC-122, CC-885 and CC-220. b IMiDs (purple rhombuses) bind to CRBN, a substrate receptor of CRL4 E3 ligase, to recruit substrates for ubiquitination and proteasomal degradation. Ub, ubiquitin

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Biomarker Research

ISSN: 2050-7771

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