Table 1 Demographic and biochemical characteristics of normal subjects, prodromal AD, and AD dementia

Number of subjects

101

50

23

28

Age

101

72.0 (6.1)

71.1 (8.6)

69.4 (6.0)

0.262

Years of education

101

9.5 (5.0)

8.0 (4.7)

6.70 (3.8) ^a

0.033

Gender, female, n (%)

101

26.0 (52.0)

12 (52.2)

17.0 (60.7)

0.736

K-MMSE score

101

26.8 (2.3)

25.3 (3.9)

17.9 (5.4) ^{a, b}

< 0.001

CDR

101

0.3 (0.2)

0.5 (0.0) ^a

0.9 (0.4) ^{a, b}

< 0.001

CDR sum of boxes

101

0.5 (0.6)

1.3 (0.6)

5.1 (2.6) ^{a, b}

< 0.001

GDS

101

1.6 (0.5)

3.0 (0.2) ^a

4.1 (0.9) ^{a, b}

< 0.001

B-ADL

101

20.0 (0.0)

20.0 (0.2)

19.0 (1.8) ^{a, b}

< 0.001

I-ADL

101

0.04 (0.08)

0.22 (0.14) ^a

0.63 (0.20) ^{a, b}

< 0.001

 Aβ_1–42, pg/ml

101

1,059 (177)

550 (223) ^a

484 (192) ^a

< 0.001

 t-Tau, pg/ml

101

230 (77)

389 (236) ^a

536 (209) ^{a, b}

< 0.001

 p-Tau₁₈₁, pg/ml

101

44 (14)

66 (33) ^a

78 (28) ^a

< 0.001

 BK, pg/ml

72

83 (49)

55 (45)

39 (33) ^a

0.002

 FXIIa, U/ml

101

23.90 (3.70)

28.0 (3.4) ^a

30.6 (3.7) ^a

< 0.001

 FXIa, U/ml

101

1.11 (0.21)

1.18 (0.21)

1.30 (0.30) ^a

0.005

 FXa, U/ml

101

0.77 (0.11)

0.81 (0.12)

0.97 (0.29) ^{a, b}

< 0.001

 Kallikrein, U/ml

101

1.20 (0.25)

1.35 (0.34)

1.54 (0.39) ^a

< 0.001

 BK, pg/ml

90

13,365 (9,305)

13,497 (7,945)

17,679 (21,186)

0.406